Results 111 to 120 of about 7,623,726 (294)
Mass spectrometric evidence for the underrepresented RNA-protein crosslinks [PDF]
In protein-RNA complexes, UVC crosslinks proteins predominantly to uracil. Concrete evidence for other UVC-crosslinked RNA bases is lacking. Here, I elucidate mass spectrometric signatures of UVC-crosslinked guanine, cytidine, and methyladenine. This can
Jong Woo, Bae
core +1 more source
A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]
, 2008 The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad +23 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly
Cell Reports, 2018 Summary: Eukaryotic cells contain large RNA-protein assemblies referred to as RNP granules, whose assembly is promoted by both traditional protein interactions and intrinsically disordered protein domains.
David S.W. Protter +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Protein-RNA interactions during stress responses in Saccharomyces cerevisiae [PDF]
The survival and adaptability of living organisms depend on their ability to adjust to environmental changes. In the yeast Saccharomyces cerevisiae, glucose serves as the preferential carbon and energy source.
Ristová, Michaela
core +1 more source
Predicting RNA-Protein Interactions Using Only Sequence Information
BMC Bioinformatics, 2011 Background RNA-protein interactions (RPIs) play important roles in a wide variety of cellular processes, ranging from transcriptional and post-transcriptional regulation of gene expression to host defense against pathogens. High throughput experiments to
Muppirala Usha K +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
RNA-RNA and RNA-protein interactions in coronavirus replication and transcription
, 2020 Coronavirus (CoV) RNA synthesis includes the replication of the viral genome, and the transcription of sgRNAs by a discontinuous mechanism. Both processes are regulated by RNA sequences such as the 5¿ and 3¿ untranslated regions (UTRs), and the ...
Solá Gurpegui, Isabel +4 more
core +1 more source
Computational approaches for investigating protein-ligand interactions - towards an in-depth understanding of the dengue virus methyltransferase [PDF]
, 2013 Interactions between proteins and their ligands play crucial roles in many biological processes, such as metabolism, signaling, transport, regulation or molecular recognition. Understanding the molecular basis of protein-ligand interactions is thus of
Schmidt, Tobias Benjamin
core +1 more source