Results 11 to 20 of about 817,279 (353)
Protein tyrosine kinases in Schistosoma mansoni [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology.
Diana Bahia +4 more
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BY-kinases: Protein tyrosine kinases like no other. [PDF]
J Biol Chem, 2023 BY-kinases (for bacterial tyrosine kinases) constitute a family of protein tyrosine kinases that are highly conserved in the bacterial kingdom and occur most commonly as essential components of multicomponent assemblies responsible for the biosynthesis, polymerization, and export of complex polysaccharides involved in biofilm or capsule formation.
Hajredini F, Alphonse S, Ghose R.
europepmc +3 more sources
Bacterial Protein-Tyrosine Kinases [PDF]
Current Proteomics, 2010 Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTP-binding ...
Shi, Lei +3 more
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Structural biology of protein tyrosine kinases
Cellular and Molecular Life Sciences, 2006 Our current understanding of the structure, mechanism of action and modes of regulation of the protein tyrosine kinase family owes a great deal to structural biology. Structures are now available for more than 20 different tyrosine kinase domains, many of these in multiple conformational states.
S. Cowan-Jacob
semanticscholar +3 more sources
Induction of phagocytosis by a protein tyrosine kinase [PDF]
Blood, 1995 The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit.
Zena K. Indik +3 more
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Frontiers in Microbiology, 2014 Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets.
Lei eShi +9 more
doaj +1 more source
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
doaj +1 more source
The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
Cells, 2021 NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and ...
Jason Chekmarev +2 more
doaj +1 more source
Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
Kit S. Lam, Fahad Al-Obeidi
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Protein Tyrosine Kinase in Colorectal Adenoma [PDF]
Acta Oncologica, 1993 To determine whether protein tyrosine kinase (PTK) could be utilized as a biological indicator of colonic tumorigenesis, we examined the PTK activity in the cytosolic and particulate fractions of homogenates from 25 adenomas (polyps) and from adjacent normal mucosa.
Hidenori Yanagi +5 more
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