Results 11 to 20 of about 328,904 (334)
Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. [PDF]
, 2016 Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial.
Chu, Zhonghua +7 more
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A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]
PLoS ONE, 2013 CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
doaj +1 more source
Induction of phagocytosis by a protein tyrosine kinase [PDF]
Blood, 1995 The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit.
Zena K. Indik +3 more
openaire +3 more sources
Frontiers in Microbiology, 2014 Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets.
Lei eShi +9 more
doaj +1 more source
eLife, 2023 Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
Allyson Li +4 more
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Tyrosine kinases in rheumatoid arthritis
Journal of Inflammation, 2011 Rheumatoid arthritis (RA) is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses
Kobayashi Akiko, Okamoto Hiroshi
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Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
doaj +1 more source
The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
Cells, 2021 NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and ...
Jason Chekmarev +2 more
doaj +1 more source
Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
Kit S. Lam, Fahad Al-Obeidi
openaire +3 more sources
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
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