Results 11 to 20 of about 333,854 (331)
Protein tyrosine kinases in Schistosoma mansoni [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology.
Diana Bahia +4 more
doaj +4 more sources
BY-kinases: Protein tyrosine kinases like no other. [PDF]
J Biol Chem, 2023 BY-kinases (for bacterial tyrosine kinases) constitute a family of protein tyrosine kinases that are highly conserved in the bacterial kingdom and occur most commonly as essential components of multicomponent assemblies responsible for the biosynthesis, polymerization, and export of complex polysaccharides involved in biofilm or capsule formation.
Hajredini F, Alphonse S, Ghose R.
europepmc +3 more sources
Microbial protein-tyrosine kinases. [PDF]
J Biol Chem, 2014 Microbial ester kinases identified in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids was thought to be unique to eukaryotes. Current analysis of available microbial genomes reveals that "eukaryote-like" protein kinases are prevalent in prokaryotes and can converge in the same signaling pathway with ...
Chao JD, Wong D, Av-Gay Y.
europepmc +4 more sources
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
F A, Al-Obeidi, K S, Lam
openaire +2 more sources
Tyrosine kinases in rheumatoid arthritis
Journal of Inflammation, 2011 Rheumatoid arthritis (RA) is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses
Kobayashi Akiko, Okamoto Hiroshi
doaj +1 more source
The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
Cells, 2021 NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and ...
Jason Chekmarev +2 more
doaj +1 more source
Protein Tyrosine Kinase in Colorectal Adenoma [PDF]
Acta Oncologica, 1993 To determine whether protein tyrosine kinase (PTK) could be utilized as a biological indicator of colonic tumorigenesis, we examined the PTK activity in the cytosolic and particulate fractions of homogenates from 25 adenomas (polyps) and from adjacent normal mucosa.
T, Hatada +5 more
openaire +2 more sources
Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
doaj +1 more source
Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation [PDF]
, 2005 The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been ...
Buffone, Mariano Gabriel +6 more
core +1 more source