Results 11 to 20 of about 184,784 (335)
BY-kinases: Protein tyrosine kinases like no other. [PDF]
J Biol Chem, 2023 BY-kinases (for bacterial tyrosine kinases) constitute a family of protein tyrosine kinases that are highly conserved in the bacterial kingdom and occur most commonly as essential components of multicomponent assemblies responsible for the biosynthesis, polymerization, and export of complex polysaccharides involved in biofilm or capsule formation.
Hajredini F, Alphonse S, Ghose R.
europepmc +3 more sources
Microbial protein-tyrosine kinases. [PDF]
J Biol Chem, 2014 Microbial ester kinases identified in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids was thought to be unique to eukaryotes. Current analysis of available microbial genomes reveals that "eukaryote-like" protein kinases are prevalent in prokaryotes and can converge in the same signaling pathway with ...
Chao JD, Wong D, Av-Gay Y.
europepmc +5 more sources
Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. [PDF]
Cancers (Basel), 2021 Protein kinases constitute a large group of enzymes catalysing protein phosphorylation and controlling multiple signalling events. The human protein kinase superfamily consists of 518 members and represents a complicated system with intricate internal and external interactions.
K Bhanumathy K +5 more
europepmc +5 more sources
Bacterial Protein-Tyrosine Kinases [PDF]
Current Proteomics, 2010 Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTP-binding ...
Shi, Lei +3 more
openaire +3 more sources
Induction of phagocytosis by a protein tyrosine kinase [PDF]
Blood, 1995 The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit.
Zena K. Indik +3 more
openaire +3 more sources
Dynamic regulatory features of the protein tyrosine kinases. [PDF]
Biochem Soc Trans, 2019 Abstract The SRC, Abelson murine leukemia viral oncogene homolog 1, TEC and C-terminal SRC Kinase families of non-receptor tyrosine kinases (collectively the Src module kinases) mediate an array of cellular signaling processes and are therapeutic targets in many disease states.
Amatya N, Lin DY, Andreotti AH.
europepmc +5 more sources
BYKdb: the Bacterial protein tYrosine Kinase database [PDF]
Nucleic Acids Research, 2011 Bacterial tyrosine-kinases share no resemblance with their eukaryotic counterparts and they have been unified in a new protein family named BY-kinases. These enzymes have been shown to control several biological functions in the bacterial cells. In recent years biochemical studies, sequence analyses and structure resolutions allowed the deciphering of ...
Jadeau, Fanny +5 more
openaire +9 more sources
eLife, 2023 Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
Allyson Li +4 more
doaj +1 more source
Tyrosine kinases in rheumatoid arthritis
Journal of Inflammation, 2011 Rheumatoid arthritis (RA) is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses
Kobayashi Akiko, Okamoto Hiroshi
doaj +1 more source
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
doaj +1 more source