Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk [PDF]
, 2000 The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally and had no major phenotypic alterations of the immune ...
Baltimore, David +7 more
core +3 more sources
Química Nova, 2009 Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues.
Bárbara V. Silva +3 more
doaj +1 more source
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
doaj +1 more source
Efficient and Accurate Modeling of Conformational Transitions in Proteins: The Case of c-Src Kinase [PDF]
, 2018 The theoretical computational modeling of large conformational transitions occurring in biomolecules still represents a challenge. Here, we present an accurate "in silico" description of the activation and deactivation mechanisms of human c-Src kinases ...
Alexandra G. Trandafir +4 more
core +2 more sources
An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
core +1 more source
MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers
Egyptian Journal of Medical Human Genetics, 2021 Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males.
Malihe Zangoue +3 more
doaj +1 more source
Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain. [PDF]
, 2012 Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes.
Balázs Annamária +6 more
core +2 more sources
Induction of phagocytosis by a protein tyrosine kinase [PDF]
Blood, 1995 The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit.
Zena K. Indik +3 more
openaire +2 more sources
The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]
PLoS ONE, 2012 BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
doaj +1 more source
Budding and Fission Yeast Casein Kinase-I Isoforms Have Dual-Specificity Protein-Kinase Activity [PDF]
, 1994 We have examined the activity and substrate specificity of the Saccharomyces cerevisiae Hrr25p and the Schizosaccharomyces pombe Hhp1, Hhp2, and Cki1 protein kinase isoforms.
Carmel, G. +6 more
core +2 more sources