Results 21 to 30 of about 12,507,251 (357)
Statistical characterization of therapeutic protein modifications
Scientific Reports, 2017 Peptide mapping with liquid chromatography–tandem mass spectrometry (LC-MS/MS) is an important analytical method for characterization of post-translational and chemical modifications in therapeutic proteins.
Tsung-Heng Tsai +13 more
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Cryo-EM structure of a catalytic amyloid fibril
Scientific Reports, 2023 Catalytic amyloid fibrils are novel types of bioinspired, functional materials that combine the chemical and mechanical robustness of amyloids with the ability to catalyze a certain chemical reaction.
Thomas Heerde +3 more
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Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity [PDF]
, 2005 Computational protein design methods were used to predict five variants of monofunctional Escherichia coli chorismate mutase expected to maintain catalytic activity.
Keeffe, Jennifer R. +3 more
core +2 more sources
Biomolecules, 2021 The development of many severe human diseases is associated with the formation of amyloid fibrils. Most of the available information on the process of amyloid formation has been obtained from studies of small proteins and peptides, wherein the features ...
Victor Marchenkov +5 more
doaj +1 more source
Influence of mutations of Val226 on the catalytic rate of haloalkane dehalogenase [PDF]
, 1997 Haloalkane dehalogenase converts haloalkanes to their corresponding alcohols. The 3D structure, reaction mechanism and kinetic mechanism have been studied.
Janssen, Dick B., +3 more
core +2 more sources
Protein-protein interaction prediction for targeted protein degradation [PDF]
International Journal of Molecular Sciences, 2022 AbstractProtein-protein interactions (PPIs) play a fundamental role in various biological functions; thus, detecting PPI sites is essential for understanding diseases and developing new drugs. PPI prediction is of particular relevance for the development of drugs employing targeted protein degradation, as their efficacy relies on the formation of a ...
Oliver Orasch +5 more
openaire +2 more sources
Current Opinion in Structural Biology, 2013 We are proud to present the first edition of the Protein–protein interactions Section of Current Opinion in Structural Biology. The Section is new, but the topic has been present in the journal from the very start. Volume 1, Issue 1, dated February 1991, had a review by Janin entitled Protein–protein interactions and assembly, and others by Bode and ...
Janin, Joel, Bonvin, Alexandre M. J. J.
openaire +3 more sources
Transient protein-protein interactions [PDF]
Protein Engineering Design and Selection, 2011 Transient complexes are crucial for diverse biological processes such as biochemical pathways and signaling cascades in the cell. Here, we give an overview of the transient interactions; the importance of transient interactions as drug targets; and the structural characterization of transient protein-protein complexes based on the geometrical and ...
Saliha Ece, Acuner Ozbabacan +3 more
openaire +2 more sources
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]
, 2015 Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C +9 more
core +1 more source
Epitope mapping using mRNA display and a unidirectional nested deletion library [PDF]
, 2005 In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library.
Ja, William W. +2 more
core +1 more source