Results 251 to 260 of about 287,910 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity. [PDF]

Autophagy
Sun LH, Lange CM, Hansen M, Kumsta C.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Influence of N^ε-Lysine Acetylation on the Formation of Protein Aggregates and Antibiotic Persistence in E. coli. [PDF]

Molecules
Stojowska-Swędrzyńska K, Kuczyńska-Wiśnik D, Laskowska E.   +2 more
europepmc   +1 more source

Correction to Supporting Information for Takaki and Thirumalai, Sequence complexity and monomer rigidity control the morphologies and aging dynamics of protein aggregates. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL. [PDF]

J Clin Invest
Dupré N, Gueniot F, Domenga-Denier V, Dubosclard V, Nilles C, Hill-Eubanks D, Morgenthaler-Roth C, Nelson MT, Keime C, Danglot L, Joutel A.   +10 more
europepmc   +1 more source

Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease

Cox D, Burke M, Milani S, White MA, Waldron FM, Böken D, Lobanova E, Sreedharan J, Gregory JM, Klenerman D.   +9 more
europepmc   +1 more source

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates. [PDF]

iScience
Marques M, Ramos B, Albuquerque H, Pereira M, Ribeiro DR, Nunes A, Sarabando J, Brás D, Ferreira AR, Vitorino R, Amorim MJ, Silva AMS, Soares AR, Ribeiro D.   +13 more
europepmc   +1 more source