Results 271 to 280 of about 287,910 (304)
Some of the next articles are maybe not open access.
DNAJ Proteins and Protein Aggregation Diseases
Current Topics in Medicinal Chemistry, 2013Many neurodegenerative diseases are late onset diseases, associated with aggregation of proteins, implying that aged cells are more susceptible to proteotoxic stress. It is known that with aging, there is a decline in the functionality of chaperone networks and on the other hand, accumulation of damaged proteins occurs.
Vaishali, Kakkar +2 more
openaire +2 more sources
Molecular simulation of protein aggregation
Biotechnology and Bioengineering, 2006AbstractComputer simulation offers unique possibilities for investigating molecular‐level phenomena difficult to probe experimentally. Drawing from a wealth of studies concerning protein folding, computational studies of protein aggregation are emerging.
Dusan, Bratko +3 more
openaire +2 more sources
Prediction of protein aggregation
The scientific community is very interested in protein aggregation because of its involvement in several neurodegenerative diseases and its significance in industry. Remarkably, fibrillar aggregates are utilized naturally for constructing structural scaffolds or creating biological switches and may be intentionally designed to construct versatile ...Kavyan, Khalili +3 more
openaire +2 more sources
Protein Aggregation in Congenital Myopathies
Seminars in Pediatric Neurology, 2011Protein aggregation in congenital myopathies may be encountered among different myofibrillar myopathies such as granulofilamentous myopathy, cytoplasmic body myopathy, or spheroid body myopathy, which are designated as αB crystallinopathy, desminopathy, and myotilinopathy, respectively, according to the respective mutant proteins.
Hans H, Goebel, Astrid, Blaschek
openaire +2 more sources
Protein folding and aggregation in bacteria
Cellular and Molecular Life Sciences, 2010Proteins might experience many conformational changes and interactions during their lifetimes, from their synthesis at ribosomes to their controlled degradation. Because, in most cases, only folded proteins are functional, protein folding in bacteria is tightly controlled genetically, transcriptionally, and at the protein sequence level.
Raimon, Sabate +2 more
openaire +2 more sources
Effect of Additives on Protein Aggregation
Current Pharmaceutical Biotechnology, 2009This paper overviews solution additives that affect protein stability and aggregation during refolding, heating, and freezing processes. Solution additives are mainly grouped into two classes, i.e., protein denaturants and stabilizers. The former includes guanidine, urea, strong ionic detergents, and certain chaotropic salts; the latter includes ...
Hiroyuki, Hamada +2 more
openaire +2 more sources
International Journal of Biological Macromolecules, 2017
Ipsita, Roy, Boris I, Kurganov
openaire +3 more sources
Ipsita, Roy, Boris I, Kurganov
openaire +3 more sources
Mechanisms of Prion Protein Aggregation
Protein & Peptide Letters, 2009The prion protein is a cell surface glycoprotein that is converted to a protease resistant abnormal isoform during the course of prion disease. The normal isoform of this protein has been shown to be an antioxidant that aids the survival of neurones.
Sarah N, Fontaine, David R, Brown
openaire +2 more sources
Neurodegenerative disorders of protein aggregation
Neurochemistry International, 2003In recent years, it has become increasingly clear that many neurodegenerative diseases involve aggregation and deposition of misfolded proteins such as amyloid beta, tau, alpha-synuclein and polyglutamine containing proteins. This abnormal deposition of misfolded proteins produce malfunctioning of a distinctive set of neurons.
openaire +2 more sources
In Vitro Cellular & Developmental Biology - Animal, 1996
J, Prachar, K, Hlubinova, A, Feldsamova
openaire +2 more sources
J, Prachar, K, Hlubinova, A, Feldsamova
openaire +2 more sources