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Physicochemical Principles of Protein Aggregation

2013
This chapter provides a theoretical framework on the quantitative description of protein aggregation. The reader is provided with an overview of the fundamental theory of linear and helical polymers, as well as an introduction on the parameters governing evolution of aggregates over time.
Bolognesi B., Tartaglia G. G.
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Protein aggregation: An overview

In order for an ordered protein to perform its specific function, it must have a specific molecular structure. Information about this structure is encoded in the protein's amino acid sequence. The unique functional state is achieved as a result of a specific process, known as protein folding. However, as a result of partial or complete unfolding of the
Bahareh, Dabirmanesh, Khosro, Khajeh, Vladimir N, Uversky   +2 more
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Reversal of Protein Aggregation Provides Evidence for Multiple Aggregated States

Journal of Molecular Biology, 2005
Observations that prefibrillar aggregates from different amyloidogenic proteins can be solubilised under some conditions have raised questions as to the generality of this phenomenon and the nature of the factors that influence it. By studying aggregates formed from human muscle acylphosphatase (AcP) under mild denaturing conditions, and by using a ...
CALAMAI M., CANALE C., RELINI A., STEFANI, MASSIMO, CHITI, FABRIZIO, DOBSON C. M.   +5 more
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DNAJ Proteins and Protein Aggregation Diseases

Current Topics in Medicinal Chemistry, 2013
Many neurodegenerative diseases are late onset diseases, associated with aggregation of proteins, implying that aged cells are more susceptible to proteotoxic stress. It is known that with aging, there is a decline in the functionality of chaperone networks and on the other hand, accumulation of damaged proteins occurs.
Vaishali, Kakkar, Louis C B, Prins, Harm H, Kampinga   +2 more
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Molecular simulation of protein aggregation

Biotechnology and Bioengineering, 2006
AbstractComputer simulation offers unique possibilities for investigating molecular‐level phenomena difficult to probe experimentally. Drawing from a wealth of studies concerning protein folding, computational studies of protein aggregation are emerging.
Dusan, Bratko, Troy, Cellmer, John M, Prausnitz, Harvey W, Blanch   +3 more
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Prediction of protein aggregation

The scientific community is very interested in protein aggregation because of its involvement in several neurodegenerative diseases and its significance in industry. Remarkably, fibrillar aggregates are utilized naturally for constructing structural scaffolds or creating biological switches and may be intentionally designed to construct versatile ...
Kavyan, Khalili, Farnoosh, Farzam, Bahareh, Dabirmanesh, Khosro, Khajeh   +3 more
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Protein Aggregation in Congenital Myopathies

Seminars in Pediatric Neurology, 2011
Protein aggregation in congenital myopathies may be encountered among different myofibrillar myopathies such as granulofilamentous myopathy, cytoplasmic body myopathy, or spheroid body myopathy, which are designated as αB crystallinopathy, desminopathy, and myotilinopathy, respectively, according to the respective mutant proteins.
Hans H, Goebel, Astrid, Blaschek
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Protein folding and aggregation in bacteria

Cellular and Molecular Life Sciences, 2010
Proteins might experience many conformational changes and interactions during their lifetimes, from their synthesis at ribosomes to their controlled degradation. Because, in most cases, only folded proteins are functional, protein folding in bacteria is tightly controlled genetically, transcriptionally, and at the protein sequence level.
Raimon, Sabate, Natalia S, de Groot, Salvador, Ventura   +2 more
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Effect of Additives on Protein Aggregation

Current Pharmaceutical Biotechnology, 2009
This paper overviews solution additives that affect protein stability and aggregation during refolding, heating, and freezing processes. Solution additives are mainly grouped into two classes, i.e., protein denaturants and stabilizers. The former includes guanidine, urea, strong ionic detergents, and certain chaotropic salts; the latter includes ...
Hiroyuki, Hamada, Tsutomu, Arakawa, Kentaro, Shiraki   +2 more
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Mechanisms of Prion Protein Aggregation

Protein & Peptide Letters, 2009
The prion protein is a cell surface glycoprotein that is converted to a protease resistant abnormal isoform during the course of prion disease. The normal isoform of this protein has been shown to be an antioxidant that aids the survival of neurones.
Sarah N, Fontaine, David R, Brown
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