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Protein aggregation in neurodegenerative diseases [PDF]
Chinese Medical Journal. Neurodegenerative diseases constitute a group of chronic disorders characterized by the progressive loss of neurons. Major neurodegenerative conditions include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal lobar ...
Jiannan Wang +3 more
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Plant-Based Inhibitors of Protein Aggregation [PDF]
BiomoleculesThe assembly of amyloidogenic proteins and peptides into toxic oligomeric and fibrillar aggregates is closely connected to the onset and progression of more than 50 protein diseases, such as Alzheimer’s disease, Parkinson’s disease, prion disease, and ...
Olha Zhytniakivska +2 more
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Spatial control of irreversible protein aggregation [PDF]
eLife, 2019 Liquid cellular compartments form in the cyto- or nucleoplasm and can regulate aberrant protein aggregation. Yet, the mechanisms by which these compartments affect protein aggregation remain unknown. Here, we combine kinetic theory of protein aggregation
Christoph Weber +2 more
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Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation [PDF]
Frontiers in Aging Neuroscience, 2017 Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer’s disease.
Nicole Groh +9 more
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Targeting Protein Aggregation in ALS [PDF]
BiomoleculesProteinopathies involve the abnormal accumulation of specific proteins. Maintaining the balance of the proteome is a finely regulated process managed by a complex network of cellular machinery responsible for protein synthesis, folding, and degradation ...
Michele Perni, Benedetta Mannini
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Moderate Protein Processing: Elucidation of Thermal Aggregation and Gel Quality and Regulatory Strategies for Excessive Aggregation [PDF]
Shipin Kexue, 2023 Heat treatment can induce muscle protein denaturation and aggregation and eventually the sol-gel tradition of proteins. The aggregation rate, degree, morphology and pattern can affect the quality of protein gels.
HAN Zongyuan, SHAO Junhua, PAN Yanmo, CHENG Kaixing, SUN Qinxiu, WEI Shuai, XIA Qiuyu, WANG Zefu, LIU Shucheng
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Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms. [PDF]
PLoS Computational Biology, 2015 Protein aggregation is a hallmark of over 30 human pathologies. In these diseases, the aggregation of one or a few specific proteins is often toxic, leading to cellular degeneration and/or organ disruption in addition to the loss-of-function resulting ...
Greet De Baets +3 more
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A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation
Life, 2021 How proteins properly fold and maintain solubility at the risk of misfolding and aggregation in the cellular environments still remains largely unknown.
Seong Il Choi, Baik L. Seong
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Computational and Structural Biotechnology Journal, 2020 Protein aggregation is a widespread phenomenon that stems from the establishment of non-native intermolecular contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic property of polypeptide
Jaime Santos +4 more
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α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
Neural Regeneration Research, 2023 The misfolding and aggregation of α-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy.
Alessandra Bigi +2 more
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