Results 21 to 30 of about 7,628,689 (242)
Computational methods to predict protein aggregation.
Current Opinion in Structural Biology, 2022 In most cases, protein aggregation stems from the establishment of non-native intermolecular contacts. The formation of insoluble protein aggregates is associated with many human diseases and is a major bottleneck for the industrial production of protein-
Susanna Navarro, S. Ventura
semanticscholar +1 more source
Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones
mBio, 2022 With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular mechanisms by which copper causes cell death are not ...
Lisa Zuily +12 more
semanticscholar +1 more source
A guide to studying protein aggregation
The FEBS Journal, 2021 Disrupted protein folding or decreased protein stability can lead to the accumulation of (partially) un‐ or misfolded proteins, which ultimately cause the formation of protein aggregates. Much of the interest in protein aggregation is associated with its
J. Housmans +3 more
semanticscholar +1 more source
Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids.
Chemical Reviews, 2021 This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are an important hallmark of protein misfolding diseases and therefore have been investigated for decades. Only recently, however, atomic or near-atomic resolution
D. Willbold +4 more
semanticscholar +1 more source
Effect of Buffer on Protein Stability in Aqueous Solutions: A Simple Protein Aggregation Model
Journal of Physical Chemistry B, 2021 Liquid–liquid phase separation (LLPS) of proteins has recently been associated with the onset of numerous diseases. Despite several studies in this area of protein aggregation, buffer-specific effects always seem to be overlooked.
Sandi Brudar, B. Hribar-Lee
semanticscholar +1 more source
Tracking protein aggregate interactions [PDF]
Prion, 2011 Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis ( 1, 2) . At each fibril end, β-sheets provide a template for recruiting and converting monomers ( 3) . Various amyloid fibrils often occur in the same individual, yet whether distinct protein aggregates aid or inhibit the assembly of
Nilsson, K. Peter R. +2 more
openaire +2 more sources
Protein Aggregation as a Bacterial Strategy to Survive Antibiotic Treatment
Frontiers in Molecular Biosciences, 2021 While protein aggregation is predominantly associated with loss of function and toxicity, it is also known to increase survival of bacteria under stressful conditions.
Celien Bollen +2 more
semanticscholar +1 more source
Computational and Structural Biotechnology Journal, 2020 Protein aggregation is a widespread phenomenon that stems from the establishment of non-native intermolecular contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic property of polypeptide
Jaime Santos +4 more
doaj +1 more source
Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms. [PDF]
PLoS Computational Biology, 2015 Protein aggregation is a hallmark of over 30 human pathologies. In these diseases, the aggregation of one or a few specific proteins is often toxic, leading to cellular degeneration and/or organ disruption in addition to the loss-of-function resulting ...
Greet De Baets +3 more
doaj +1 more source
A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation
Life, 2021 How proteins properly fold and maintain solubility at the risk of misfolding and aggregation in the cellular environments still remains largely unknown.
Seong Il Choi, Baik L. Seong
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