Results 31 to 40 of about 737,165 (295)

Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae [PDF]

, 2017
The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed.
Keefer, Kathryn M, Stein, Kevin C, true, Heather L   +2 more
core   +2 more sources

Amyloids and protein aggregation

Chemical Science, 2023
Sara Linse and Tuomas Knowles introduce the Chemical Science themed collection on the topic of amyloids and protein aggregation.
Sara Linse, Tuomas Knowles
openaire   +2 more sources

Why and how protein aggregation has to be studied in vivo

Microbial Cell Factories, 2013
The understanding of protein aggregation is a central issue in different fields of protein science, from the heterologous protein production in biotechnology to amyloid aggregation in several neurodegenerative and systemic diseases.
Ami Diletta, Natalello Antonino, Lotti Marina, Doglia Silvia Maria   +3 more
doaj   +1 more source

An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins. [PDF]

PLoS Computational Biology, 2011
We previously showed the existence of selective pressure against protein aggregation by the enrichment of aggregation-opposing 'gatekeeper' residues at strategic places along the sequence of proteins.
Greet De Baets, Joke Reumers, Javier Delgado Blanco, Joaquin Dopazo, Joost Schymkowitz, Frederic Rousseau   +5 more
doaj   +1 more source

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. [PDF]

, 2018
The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-complexity domain (LCD) is believed to be involved in both types of aggregation. To
A Jain, A Molliex, A Patel, A Saini, A Soragni, AE Conicella, AF Harrison, AJ McCoy, AK Chen, AK Walker, AWP Fitzpatrick, C Amador-Ortiz, C Colombrita, C Lagier-Tourenne, C Schwab, C Yang, C-H Chiang, CK Chang, CM Dewey, Collaborative Computational Project, Number 4., D Shi, DA Bosco, David R. Boyer, David S. Eisenberg, DS Eisenberg, DT Murray, Duilio Cascio, E Bentmann, E Buratti, E Kabashi, EB Lee, Elizabeth L. Guenther, EM Marcotte, F Meersman, GM Sheldrick, GN Murshudov, GS Pesiridis, H Nakashima-Yasuda, Hamilton Trinh, HB Schmidt, HJ Dyson, HJ Kim, HY Zoghbi, J Hattne, JA Rodriguez, Jiahui Lu, JJ Wiltzius, Jose A. Rodriguez, JP Ling, JR Wheeler, L Goldschmidt, L Lim, LC Reineke, LL Jiang, LL Jiang, LM Igaz, M Budini, M Cushman, M Hasegawa, M Kato, M Mompeán, M Neumann, M Xu, MA Gitcho, Masato Kato, MC Lawrence, MD Winn, Michael P. Hughes, Michael R. Sawaya, MP Hughes, MR Sawaya, N Gilks, N Kedersha, P Emsley, P Hackman, P-N Cheng, PD Adams, PJ Lukavsky, PM Seidler, PS Estes, Qin Cao, RA Fuentealba, S Higashi, S Xiang, SC Ling, TM Franzmann, TPJ Knowles, W Guo, W Kabsch, W Kabsch, Y Dang, Y Lin, Z Otwinowski, ZM March   +93 more
core   +1 more source

Protein aggregation in bacteria [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm, Kristen Schroeder, Kristina Jonas   +2 more
openaire   +3 more sources

Cell Death via Lipid Peroxidation and Protein Aggregation Diseases

Biology, 2021
Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi, Tomoka Takai, Hisashi Hisatomi   +2 more
doaj   +1 more source

Protein folding disorders: Toward a basic biological paradigm [PDF]

, 2010
Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core   +3 more sources

The RNA-Binding Protein Scp160p Facilitates Aggregation of Many Endogenous Q/N-Rich Proteins

Cell Reports, 2018
Summary: The RNA-binding protein Scp160p is the yeast homolog of the conserved vigilin protein family. These proteins influence a variety of nuclear and cytoplasmic functions.
Matthew H.K. Cheng, Patrick C. Hoffmann, Mirita Franz-Wachtel, Carola Sparn, Charlotte Seng, Boris Maček, Ralf-Peter Jansen   +6 more
doaj   +1 more source

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

eLife, 2022
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink   +16 more
doaj   +1 more source