Results 31 to 40 of about 7,628,689 (242)
α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
Neural Regeneration Research, 2023 The misfolding and aggregation of α-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy.
Alessandra Bigi +2 more
doaj +1 more source
Protein aggregation and bioprocessing [PDF]
The AAPS Journal, 2006 Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced during the cell culture and purification process by carefully controlling the environment (eg, media components) and implementing appropriate strategies to minimize the extent of aggregation.
Mary E M, Cromwell +2 more
openaire +2 more sources
Uncovering the Mechanism of Aggregation of Human Transthyretin. [PDF]
, 2015 The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis.
Cascio, Duilio +9 more
core +2 more sources
Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays. [PDF]
PLoS ONE, 2012 Aging-related neurodegenerative disorders, such as Parkinson's, Alzheimer's and Huntington's diseases, are characterized by accumulation of protein aggregates in distinct neuronal cells that eventually die. In Huntington's disease, the protein huntingtin
Aviv Cohen +3 more
doaj +1 more source
Sequence-specific protein aggregation generates defined protein knockdowns in plants [PDF]
, 2016 Protein aggregation is determined by short (5-15 amino acids) aggregation-prone regions (APRs) of the polypeptide sequence that self-associate in a specific manner to form beta-structured inclusions.
Aesaert, Stijn +16 more
core +2 more sources
Non-Arrhenius Protein Aggregation [PDF]
The AAPS Journal, 2013 Protein aggregation presents one of the key challenges in the development of protein biotherapeutics. It affects not only product quality but also potentially impacts safety, as protein aggregates have been shown to be linked with cytotoxicity and patient immunogenicity.
Wei, Wang, Christopher J, Roberts
openaire +2 more sources
Protein Aggregation and Immunogenicity of Biotherapeutics.
International journal of pharmaceutics, 2020 Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the manufacturing and formulation of protein biologic products is the tendency for the active pharmaceutical ingredients to aggregate, resulting in irreversible drug loss ...
N. Pham, W. Meng
semanticscholar +1 more source
Aggregation is a Context-Dependent Constraint on Protein Evolution
Frontiers in Molecular Biosciences, 2021 Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important
Michele Monti +9 more
doaj +1 more source
Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates [PDF]
, 2018 Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein's native conformation, which ultimately results in its aggregation or ...
Mata Cabana, Alejandro +3 more
core +2 more sources
Brain Science, 2020 The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function.
Larissa-Nele Schaffert, W. Carter
semanticscholar +1 more source