Results 121 to 130 of about 583,434 (343)

Profiling of the antibody response to attenuated LC16m8 smallpox vaccine using protein array analysis

, 2019
journal ...
Saito, Tomoya, 金谷, 泰宏, 3363, 3362, 藤田, 真敬, 3361, エトウ, アキコ, 3360, Kanatani, Yasuhiro, 江藤, 亜紀子, 50291125, Nishiyama, Yasumasa, 3359, 3358, 951, 932, Fujita, Masanori, Shinmura, Yasuhiko, Saijo, Masayuki, Eto, Akiko, Molina, Douglas M, 40506317, 森川, 茂, Morikawa, Shigeru, カナタニ, ヤスヒロ, 齋藤, 智也, 723, 80327501, サイトウ, トモヤ, 西條, 政幸   +29 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Tick lipocalin triggers mammalian IGFBP-3-mediated apoptosis in macrophages and keratinocytes

Frontiers in Immunology
Ticks secrete several molecules, including lipocalins, in their saliva during blood feeding on a vertebrate host. In this study, we provide novel evidence on the role of Ornithodoros turicata americanus tick lipocalin (Otlip) in modulating cytokine ...
Krittika Nandy, P. P. Mahesh, Lichao Liu, Daniel E. Sonenshine, Daniel E. Sonenshine, Hameeda Sultana, Girish Neelakanta   +6 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7

BMC Genomics, 2008
Background Protein kinases and phosphatases regulate protein phosphorylation, a critical means of modulating protein function, stability and localization.
Neszt Michael, Zadworny Megan, Por Hanting, Knockleby James, Szapiel Nicolas, Nguyen Thao, Logan Michael R, Harrison Paul, Bussey Howard, Mandato Craig A, Vogel Jackie, Lesage Guillaume   +11 more
doaj   +1 more source

A motif-based analysis of glycan array data to determine the specificities of glycan-binding proteins [PDF]

, 2009
Andrew P. Porter, Tingting Yue, Lee Heeringa, Steven M. Day, Edward Suh, Brian B. Haab   +5 more
openalex   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis

BMC Genomics, 2008
Background Functional genomics has received considerable attention in the post-genomic era, as it aims to identify function(s) for different genes. One way to study gene function is to investigate the alterations in the responses of deletion mutants to ...
Eroukova Veronika, Alamgir Md, Jessulat Matthew, Xu Jianhua, Golshani Ashkan   +4 more
doaj   +1 more source

Combined Oligonucleotide and Protein Microarray Temporal Analysis of p53-mediated Apoptosis

, 2005
Background: P53-mediated apoptosis involves a complex process induced largely by p53 acting as a transcription factor. We hypothesised that p53 expression would lead to transcriptional events that rapidly change during apoptosis and that protein array ...
Bailey A., Wee E., Lambe T., Ogg G.S., Jones L., Black A.P.   +5 more
core  

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source