Results 221 to 230 of about 2,014,238 (321)

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence-Associated Traits. [PDF]

Aging Cell
Abdelmohsen K, Martindale JL, Rossi M, Shin CH, Pal A, Munk R, Salamini-Montemurri M, Baranzini M, Arends EM, Mustapic M, Lee Y, Lee JN, Popma SH, Hu J, Duda N, Nogueras-Ortiz CJ, Kapogiannis D, Cui CY, Gorospe M.   +18 more
europepmc   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma. [PDF]

Transl Vis Sci Technol
Kocherlakota S, Nicol A, Locri F, Stebbins KJ, Lorrain DS, Tribble JR, Williams PA.   +6 more
europepmc   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Basophils activate splenic B cells and dendritic cells via IL-13 signaling in acute traumatic brain injury. [PDF]

J Neuroinflammation
Olde Heuvel F, Zhang J, Sun F, Krishnamurthy SS, Yartas G, Özkan B, Pagliarini M, Voehringer D, O'Meara CC, Schäfer MKE, Huber-Lang M, Roselli F.   +11 more
europepmc   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Atom-level machine learning of protein-glycan interactions and cross-chiral recognition in glycobiology. [PDF]

Sci Adv
Carpenter EJ, Peng C, Haregu S, Twells N, Woudstra L, Sood A, Cartmell J, Woods RJ, Mahal LK, Wang SK, Greiner R, Derda R.   +11 more
europepmc   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Nuclear poly(A)-binding protein and nucleolin utilize their RNA recognition motifs to read PAR chains. [PDF]

Nucleic Acids Res
Shi L, Dasovich M, Horton JR, Liu H, Zhan Q, Manickavinayaham S, Jeter CR, Mixon IJ, Zehrbach NM, Ishak CA, Yoon JH, Cheng X, Leung AKL, Bedford MT.   +13 more
europepmc   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source