Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants. [PDF]
Ala-Kulju K+3 more
europepmc +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu+4 more
wiley +1 more source
Identification of Soy-Derived Peptides With Micelle Disruption Activity of Secondary Bile Acids. [PDF]
Shimizu S+5 more
europepmc +1 more source
State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis+6 more
wiley +1 more source
An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments [PDF]
Zhizhong Yin+4 more
openalex +1 more source
Investigation and design of the dual specificity of the PRDM9 protein lysine methyltransferase. [PDF]
Graf D+4 more
europepmc +1 more source
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban+5 more
wiley +1 more source
Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang+12 more
wiley +1 more source
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity. [PDF]
Ali FH+10 more
europepmc +1 more source