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Single layer linear array of microbeads for multiplexed analysis of DNA and proteins
Biosensors and Bioelectronics, 2014In this study, a microfluidic platform was developed to generate single layer, linear array of microbeads for multiplexed high-throughput analysis of biomolecules. The microfluidic device is comprised of eight microbead-trapping units, where microbeads were immobilized in a linear array format by the exertion of a negative pressure in the control ...
Wanqing Yue+9 more
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Network-based analysis of reverse phase protein array data
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2016In this paper, we introduce a computational method for constructing networks based on reverse phase protein array (RPPA) data to identify complex patterns in protein signaling. The method is applied to phosphoproteomic profiles of basal expression and activation/phosphorylation of 76 key signaling proteins in three breast cancer cell lines (MCF7, LCC1,
Rency S. Varghese+8 more
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Conformational analysis of proteins: Algorithms and data structures for array processing
Journal of Computational Chemistry, 1980AbstractCurrent efforts to determine the nature of the interactions that influence protein folding involve, among other things, minimization of an appropriate empirical conformational energy function (ECEPP, Emprical Conformational Energy Program for Peptides) to obtain the native structure.
R. W. Tuttle+4 more
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Microwestern Arrays for Systems-Level Analysis of SH2 Domain-Containing Proteins
2017The Microwestern Array (MWA) method combines the scalability and miniaturization afforded by the Reverse Phase Lysate Array (RPLA) approach with the electrophoretic separation characteristic of the Western blot. This technology emulates the creation of an array of small Western blots on a single sheet of nitrocellulose allowing for the sensitive and ...
Mark F. Ciaccio, Richard B. Jones
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt+2 more
exaly
Exome array analysis of ischaemic stroke: results from a southern Swedish study
European Journal of Neurology, 2016M. Söderholm+11 more
semanticscholar +1 more source