Results 51 to 60 of about 927,101 (310)
Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]
, 2015 Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara +6 more
core +1 more source
Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays [PDF]
Journal of Visualized Experiments, 2014 Lysine methylation is an emerging post-translation modification and it has been identified on several histone and non-histone proteins, where it plays crucial roles in cell development and many diseases. Approximately 5,000 lysine methylation sites were identified on different proteins, which are set by few dozens of protein lysine methyltransferases ...
Denis Kusevic +3 more
openaire +3 more sources
Acta Medica, 2008 Tumour progression requires the presence of a rich vascular supply. A number of cytokines, chemokines and proteases participate in the process of tumour angiogenesis.
Dagmar Hlávková +8 more
doaj +1 more source
Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]
, 2010 At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick +6 more
core +2 more sources
Proteomics, pathway array and signaling network-based medicine in cancer
Cell Division, 2009 Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying protein signaling network changes, including cell
Xu Hong +15 more
doaj +1 more source
Data mining of gene arrays for biomarkers of survival in ovarian cancer [PDF]
, 2015 The expected five-year survival rate from a stage III ovarian cancer diagnosis is a mere 22%; this applies to the 7000 new cases diagnosed yearly in the UK.
Ball, GR +4 more
core +2 more sources
A Network-based Analysis of Polyanion-binding Proteins Utilizing Yeast Protein Arrays [PDF]
Molecular & Cellular Proteomics, 2006 The high affinity of certain cellular polyanions for many proteins (polyanion-binding proteins (PABPs)) has been demonstrated previously. It has been hypothesized that such polyanions may be involved in protein structure stabilization, stimulation of folding through chaperone-like activity, and intra- and extracellular protein transport as well as ...
Aaron Smalter +6 more
openaire +3 more sources
ProtVec: A Continuous Distributed Representation of Biological Sequences [PDF]
PLoS ONE 10(11): e0141287, 2015, 2015 We introduce a new representation and feature extraction method for biological sequences. Named bio-vectors (BioVec) to refer to biological sequences in general with protein-vectors (ProtVec) for proteins (amino-acid sequences) and gene-vectors (GeneVec) for gene sequences, this representation can be widely used in applications of deep learning in ...
arxiv +1 more source
Metabolites, 2021 Zinc plays a pivotal role in the function of cells and can induce apoptosis in various cancer cells, including Raji B lymphoma. However, the metabolic mechanism of Zn-induced apoptosis in Raji cells has not been explored.
Naeun Yoon +10 more
doaj +1 more source
Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU [PDF]
, 2002 Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by ...
Hoff, Kevin G. +4 more
core +1 more source