Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Advanced Science, EarlyView.This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang +16 more
wiley +1 more source
Down-regulation of the bacterial protein biosynthesis machinery in response to weeks, years, and decades of soil warming. [PDF]
Sci Adv, 2022 Söllinger A +11 more
europepmc +1 more source
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. [PDF]
, 2019 Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Bold, Richard J +21 more
core
Advanced Science, EarlyView.Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu +12 more
wiley +1 more source
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides. [PDF]
ACS Chem Biol, 2021 Guerrero PA +5 more
europepmc +1 more source
Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products
Synthetic and Systems Biotechnology, 2018 Natural products with significant biological activities continuously act as rich sources for drug discovery and development. To harness the potential of these valuable compounds, robust methods need to be developed for their rapid and sustainable ...
Jian Li, Lingkai Zhang, Wanqiu Liu
doaj
Advanced Science, EarlyView.The article presents the development of artificial lipid droplets (aLDs) as biomimetic nanocarriers to enhance intramuscular fat (IMF) content in pigs. These aLDs, loaded with oleic acid, significantly increase IMF by up to 35% in muscle tissues without adverse side effects. This innovative approach improves pork quality by enhancing marbling, offering
Pengxiang Zhao +8 more
wiley +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source
Structural and Functional Elucidation of IF-3 Protein of Chloroflexus aurantiacus Involved in Protein Biosynthesis: An In Silico Approach. [PDF]
Biomed Res Int, 2021 Saikat ASM +7 more
europepmc +1 more source
Biosynthesis and intracellular translocation of mitochondrial proteins bindin protein. [PDF]
, 1978 Dutton, P. Leslie +5 more
core +1 more source