Results 111 to 120 of about 6,508,178 (232)

Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine [PDF]

, 2014
Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use.
Babaei, H., Eghbal, M.A., Heidari, R.
core   +1 more source

Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion. [PDF]

, 2017
Blood banks use pathogen inactivation (PI) technologies to increase the safety of platelet concentrates (PCs). The characteristics of PI-treated PCs slightly differ from those of untreated PCs, but the underlying reasons are not well understood.
Abonnenc, M., Lion, N., Prudent, M., Sonego, G., Tissot, J.D.   +4 more
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Heat stress impairs livestock performance through oxidative stress, immune dysregulation, and reduced productivity. Phytobiotics act as natural mitigators with antioxidant, anti‐inflammatory, antimicrobial, and gut‐modulatory effects. Mechanistically, they regulate HSPs, Nrf2, NF‐κB, and MAPK pathways.
Xiaoyan Wang, Ting Yuan, Muhammad Asif Arain, Mohammed Al‐Rasheed, Aftab Shaukat   +4 more
wiley   +1 more source

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule.
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu   +12 more
doaj   +1 more source

GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole

Neurobiology of Disease, 2006
Monosialoganglioside (GM1) is a glycosphingolipid that protects against some neurological conditions, such as seizures and ischemia. Glutaric acidemia type I (GA-I) is an inherited disease characterized by striatal degeneration, seizures, and ...
Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Mauro Schneider Oliveira, Natália Gindri Fiorenza, Roberto Frussa-Filho, João Carlos Petry, Rafael Correa Coelho, Carlos Fernando Mello   +8 more
doaj   +1 more source

The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]

, 2015
This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan, Delville, Camille, Derous, Davina, Douglas, Alex, Green, Cara Leanne, Han, Jackie J.D., Hurst, Jane, Konstantopedos, Penelope, Lusseau, David, Mitchell, Sharon E., Promislow, Daniel E. L., Speakman, John R., Wang, Yingchun   +12 more
core   +2 more sources

Protein Mediated Oxidative Stress in Patients with Diabetes and its Associated Neuropathy: Correlation with Protein Carbonylation and Disease Activity Markers.

Journal of clinical and diagnostic research : JCDR, 2017
INTRODUCTION Free radicals have been implicated as Diabetes Mellitus (DM) contributors in type 2 DM and its associated Diabetes Mellitus Neuropathy (DMN).
E. Almogbel, Naila Rasheed
semanticscholar   +1 more source

Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide

Redox Biology, 2015
Carbonylation is a generic term which refers to reactive carbonyl groups present in biomolecules due to oxidative reactions induced by reactive oxygen species.
Venukumar Vemula, Zhixu Ni, Maria Fedorova   +2 more
doaj   +1 more source