Results 101 to 110 of about 3,609,148 (217)

Small-Molecule Probe for Imaging Oxidative Stress–Induced Carbonylation in Live Cells

Bio-Protocol
Protein carbonylation has been known as the major form of irreversible protein modifications and is also widely used as an indicator of oxidative stress in the biological environment.
Ozlem Dilek, Dilek Telci, Hazel Erkan-Candag   +2 more
doaj   +1 more source

Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide

Redox Biology, 2015
Carbonylation is a generic term which refers to reactive carbonyl groups present in biomolecules due to oxidative reactions induced by reactive oxygen species.
Venukumar Vemula, Zhixu Ni, Maria Fedorova   +2 more
doaj   +1 more source

Direct Access to Alkyl Amide N‐Glycosides via Transition‐Metal‐Free Visible‐Light Carbonylation of Glycosylamines

ChemistryEurope, Volume 4, Issue 10, October 2026.
A photoredox carbonylation strategy converts glycosylamines and alkyl iodides into alkyl amide N‐glycosides. The transition‐metal‐free process uses a bench‐stable CO surrogate, preserves the anomeric configuration, and accommodates diverse carbohydrate and alkyl partners, including complex natural‐product‐derived scaffolds.
Gefei Wang, Guillaume Chu, Abdel Aziz Wayzani, Franck Le Bideau, Alexandre Vasseur, Zakaria Halime, Christophe Werlé, Ibrahim Abdellah, Samir Messaoudi   +8 more
wiley   +1 more source

The superoxide dismutase mimetic tempol does not alleviate glucocorticoid‐mediated rarefaction of rat skeletal muscle capillaries

Physiological Reports, 2017
Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid‐induced oxidative stress contributes to this phenomenon.
Erin R. Mandel, Emily C. Dunford, Ghoncheh Abdifarkosh, Patrick C. Turnbull, Christopher G. R. Perry, Michael C. Riddell, Tara L. Haas   +6 more
doaj   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Dietary Marine Oils Selectively Decrease Obesogenic Diet-Derived Carbonylation in Proteins Involved in ATP Homeostasis and Glutamate Metabolism in the Rat Cerebellum

Antioxidants
The regular intake of diets high in saturated fat and sugars increases oxidative stress and has been linked to cognitive decline and premature brain aging.
Francisco Moreno, Lucía Méndez, Ana Raner, Bernat Miralles-Pérez, Marta Romeu, Sara Ramos-Romero, Josep Lluís Torres, Isabel Medina   +7 more
doaj   +1 more source

Integrated Metabolomic and Bioenergetic Profiling Reveals Axl as a Key Regulator of Macrophage Homeostasis

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Axl deficiency disrupts peritoneal macrophage identity and function, impairing glycolysis, TCA metabolism, and mitochondrial respiration while weakening antioxidant defenses. This coordinated metabolic and redox collapse extends systemically, highlighting Axl as a key regulator of immunometabolic homeostasis.
Jesuino R M Ferreira, Thais S Rigoni, Monique S Leandro, Kamila Guimarães‐Pinto, Letícia R Ramos, André L A Costa, Clara F Carvalho, Caroline F Martiniuc, Isadora A Oliveira, Carolina Maia, Júlia Moratelli, Jefferson A Leite, Verônica S Pinto, Adriane Todeschini, Antônio Galina, Alessandra A Filardy   +15 more
wiley   +1 more source

A step-by-step protocol for assaying protein carbonylation in biological samples

, 2016
Protein carbonylation represents the most frequent and usually irreversible oxidative modification affecting proteins. This modification is chemically stable and this feature is particularly important for storage and detection of carbonylated proteins ...
M. Clerici, D. Giustarini, Dalle Donne, Isabella, Colombo, Graziano, Milzani, Aldo, GIUSTARINI, DANIELA, M. Garavaglia, A. Milzani, G. Colombo, I. Dalle Donne, Clerici, Marco, Garavaglia, Maria Elisa, R. Rossi, ROSSI, RANIERI   +13 more
core   +1 more source

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. [PDF]

, 2018
Aims: Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions.
Wiedenmann, T., Leo E. Deelman, Muckenthaler, Martina U., Deelman, L.E., Hecker, Markus, Nadine Dietrich, Sandro Altamura, Deelman, Leo E., Hecker, M., Wagner, Andreas H., Hammes, Hans-Peter, Wiedenmann, Tanja, Altamura, Sandro, Andreas H. Wagner, Hammes, H.P., Hans-Peter Hammes, Nawroth, P.P., Rob H. Henning, Fleming, Thomas, Fleming, T., Altamura, S., Dietrich, Nadine, Martina U. Muckenthaler, Wagner, A.H., Tanja Wiedenmann, Nawroth, Peter P., Henning, R.H., Dietrich, N., Muckenthaler, M.U., Henning, Rob H., Markus Hecker, Thomas Fleming, Peter P. Nawroth   +32 more
core   +1 more source