Results 91 to 100 of about 6,508,178 (232)

Investigation and identification of protein carbonylation sites based on position-specific amino acid composition and physicochemical features

BMC Bioinformatics, 2017
Protein carbonylation, an irreversible and non-enzymatic post-translational modification (PTM), is often used as a marker of oxidative stress. When reactive oxygen species (ROS) oxidized the amino acid side chains, carbonyl (CO) groups are produced ...
Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Chien-Hsun Huang, Hui-Ju Kao, Tzu-Hao Chang, Hsin-Yao Wang, Jang-Jih Lu, Tzong-Yi Lee   +8 more
semanticscholar   +1 more source

Protein Carbonylation, Mitochondrial Dysfunction, and Insulin Resistance [PDF]

Advances in Nutrition, 2013
Oxidative stress has been identified as a common mechanism for cellular damage and dysfunction in a wide variety of disease states. Current understanding of the metabolic changes associated with obesity and the development of insulin resistance has focused on the role of oxidative stress and its interaction with inflammatory processes at both the ...
Brigitte I, Frohnert, David A, Bernlohr
openaire   +2 more sources

Germinabilidad y metabolismo antioxidante en semillas de Passiflora caerulea L. expuestas a estrés salino [PDF]

, 2018
P. caerulea es la especie Passiflora con más amplia distribución en Argentina. Si bien es necesario implementar prácticas de cultivo para disminuir el impacto debido a su extracción indiscriminada, la información sobre cómo los factores ambientales ...
Causin, Humberto Fabio, Chaín, José María   +1 more
core  

HisE11 and HisF8 Provide Bis-histidyl Heme Hexa-coordination in the Globin Domain of Geobacter sulfurreducens Globin-coupled Sensor [PDF]

, 2009
Among heme-based sensors, recent phylogenomic and sequence analyses have identified 34 globin coupled sensors (GCS), to which an aerotactic or gene-regulating function has been tentatively ascribed.
ALAM M, ASCENZI P, BOLLI A, BOLOGNESI M, COLETTA M, DESMET F, DEWILDE S., GOURLAY L, MOENS L, NARDINI M, PESCE, ALESSANDRA, SISINNI L, THIJS L, VAN DOORSLAER S, WAN X   +14 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Acrolein induces selective protein carbonylation in synaptosomes [PDF]

Neuroscience, 2007
Acrolein, the most reactive of the alpha,beta-unsaturated aldehydes, is endogenously produced by lipid peroxidation, and has been found increased in the brain of patients with Alzheimer's disease. Although it is known that acrolein increases total protein carbonylation and impairs the function of selected proteins, no study has addressed which proteins
C F, Mello, R, Sultana, M, Piroddi, J, Cai, W M, Pierce, J B, Klein, D A, Butterfield   +6 more
openaire   +2 more sources

Oxidative stress and lipotoxicity

Journal of Lipid Research, 2016
The α,β polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play under both physiological and pathological conditions.
Amy K. Hauck, David A. Bernlohr
doaj   +1 more source

5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]

, 2020
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B, Brindisi, M, Cappello, AR, Curcio, R, Dolce, V, Fiorillo, M, Frattaruolo, L, Gabriele, B, Mancuso, R, Rago, V, Ziccarelli, I   +10 more
core   +2 more sources

Dietary Ergothioneine as a Novel Anti‐Aging Nutraceutical: Mechanisms, Bioavailability, and Future Perspectives

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Ergothioneine (EGT), a natural thiol derivative, has gained attention as a geroprotective nutraceutical. Preclinical research shows EGT scavenges free radicals, maintains mitochondrial integrity, slows telomere erosion, and regulates proteostasis via autophagy and senescent cell clearance.
Tian‐Tian Tian, Liang Chen, Zhen‐Zhen Dong, Chao Yang   +3 more
wiley   +1 more source

Exploring oxysterols and protein carbonylation in cervicovaginal secretions as biomarkers for cervical cancer development

Advances in Redox Research
Cervical cancer, a major global health issue and the fourth most common cancer among women, is strongly linked to Human Papillomavirus (HPV) infection.
Busra Kose, Serkan Erkanlı, Alper Koçak, Coskun Guzel, Theo Luider, Irundika H.K. Dias, Ahmet Tarik Baykal   +6 more
doaj   +1 more source