Results 81 to 90 of about 13,056 (198)

Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging

Antioxidants, 2020
Oxidative stress is a hallmark of metabolic disease, though the mechanisms that define this link are not fully understood. Irreversible modification of proteins by reactive lipid aldehydes (protein carbonylation) is a major consequence of oxidative ...
Amy K. Hauck, Tong Zhou, Ambuj Upadhyay, Yuxiang Sun, Michael B. O’Connor, Yue Chen, David A. Bernlohr   +6 more
doaj   +1 more source

Reactive Oxygen Species‐Induced Damage in Cryopreserved Bovine Sperm: Mitigation Strategies

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Cryopreservation of bovine sperm results in overproduction of ROS due to osmotic pressure variations, ice crystals and dysfunction of mitochondria, which causes lipid peroxidation, fragmentation of DNA, protein damage and ultimately decline of post‐thaw sperm quality.
Mst. Mahomudha Akhtar, Sakib Hossain, Afia Mahmuda Meem, Afiya Fairuz Lubaba, Md. Kamrul Hasan Kazal   +4 more
wiley   +1 more source

Serotonin-mediated protein carbonylation in the right heart

, 2008
Pulmonary hypertension is a devastating disease, which leads to right heart failure. Serotonin (5-HT) plays important roles in the pathogenesis Of Pulmonary hypertension and pulmonary vascular remodeling. The role of 5-HT in right heart failure. however,
Ah Mee Park, Ah-Mee Park, C. Ming Wong, Lingling Liu, MARCOCCI, Lucia, Chi Ming Wong, Yuichiro J. Suzuki, Lucia Marcocci   +7 more
core   +1 more source

Myosin Post‐Translational Modifications Associated With Critical Illness Myopathy

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Background Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and myosin content.
Fernando Ribeiro, Bruno Di Geronimo, Nicola Cacciani, Anna Widgren, Yvette Hedström, Anselmo S. Moriscot, Peter M. Kasson, Shina C. L. Kamerlin, Jonas Bergquist, Lars Larsson   +9 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule.
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu   +12 more
doaj   +1 more source

GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole

Neurobiology of Disease, 2006
Monosialoganglioside (GM1) is a glycosphingolipid that protects against some neurological conditions, such as seizures and ischemia. Glutaric acidemia type I (GA-I) is an inherited disease characterized by striatal degeneration, seizures, and ...
Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Mauro Schneider Oliveira, Natália Gindri Fiorenza, Roberto Frussa-Filho, João Carlos Petry, Rafael Correa Coelho, Carlos Fernando Mello   +8 more
doaj   +1 more source

Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide

Redox Biology, 2015
Carbonylation is a generic term which refers to reactive carbonyl groups present in biomolecules due to oxidative reactions induced by reactive oxygen species.
Venukumar Vemula, Zhixu Ni, Maria Fedorova   +2 more
doaj   +1 more source

Protein Carbonylation [PDF]

Antioxidants & Redox Signaling, 2010
Y. J. Suzuki, M. Carini, D. A. Butterfield   +2 more
openaire   +2 more sources

Protein carbonylation during natural leaf senescence in winter wheat, as probed by fluorescein-5-thiosemicarbazide

, 2015
Leaf senescence is characterised by a massive degradation of proteins in order to recycle nitrogen to other parts of the plant, such as younger leaves or developing grain/seed.
Havé, M., Leitao, L., Repellin, A., Bagard, M, Castell, Jean-François   +4 more
core   +1 more source