Results 71 to 80 of about 3,609,148 (217)

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source

Sal effect on sheep RBCs induced protein carbonylation stored in SAGM+/- Sal post thaw.

, 2016
The protein carbonylation level was determined in RBCs cryopreserved, thawed and stored in SAGM+/-Sal. The control represents protein carbonylation of fresh RBCs not subjected to freeze-thaw. The data are represented as the mean ±SD. (* = p value< 0.05).
Nigel K. H. Slater (2229784), Noha A. S. Alotaibi (3121554), Hassan Rahmoune (1555429)   +2 more
core   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases [PDF]

Journal of Cardiovascular and Thoracic Research, 2015
Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively.
Asadi Hami, Abolfathi Ali Akbar, Badalzadeh Reza, Majidinia Maryam, Yaghoubi Alireza, Asadi Maryam, Yousefi Bahman   +6 more
doaj   +1 more source

Plasma protein carbonylation in chronic uremia

Journal of Nephrology, 2011
Carbonylation is an irreversible modification caused by the introduction into proteins of carbonyl derivatives (aldehydes and ketones), which can alter protein structure and function and lead to cellular dysfunction and tissue damage. Chronic uremia may be associated with an increased carbonyl overload ("carbonyl stress"), though carbonyl formation has
Pavone B, SIROLLI, Vittorio, Giardinelli A, BUCCI, SONIA, Forli' F, Di Cesare M, SACCHETTA, Paolo, DI PIETRO, NATALIA, PANDOLFI, Assunta, Urbani A, BONOMINI, Mario   +10 more
openaire   +3 more sources

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study

Experimental Physiology, EarlyView.
Abstract Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endurance and resistance responses, on muscle protein turnover following hindlimb unloading (HU) remain ...
Tom Normand‐Gravier, Robert Solsona, Christelle Bertrand‐Gaday, Margot Issertine, Florence Sabatier, Flavie Arnould, Sébastien Racinais, Fabio Borrani, Henri Bernardi, Anthony M. J. Sanchez   +9 more
wiley   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Oxidative stress and lipotoxicity

Journal of Lipid Research, 2016
The α,β polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play under both physiological and pathological conditions.
Amy K. Hauck, David A. Bernlohr
doaj   +1 more source

Cytoprotective Effects of Organosulfur Compounds against Methimazole-Induced Toxicity in Isolated Rat Hepatocytes [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: Methimazole is a drug widely used in hyperthyroidism. However, life-threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole-induced hepatotoxicity yet.
Mohammad Ali Eghba, Hossein Babaei, Reza Heidari   +2 more
doaj   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source