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Spectrophotometric Analysis of Protein Carbonyls
2022Oxidation of proteins is a major threat to their functionality and to the sensory properties and nutritional value of meat and meat products. Moreover, the intake of protein oxidation products may also involve a potential health risk for consumers. The accurate analysis of food protein oxidation seems to be an issue of scientific and technological ...
Francesca Soglia +5 more
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Protein carbonylation: Proteomics, specificity and relevance to aging
Mass Spectrometry Reviews, 2013AbstractDetection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed the identification of the specific proteins targeted by protein carbonylation.
Cabiscol Català, Elisa +2 more
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Carbazate modified dextrans as scavengers for carbonylated proteins
Carbohydrate Polymers, 2020A series of biocompatible and non- toxic polysaccharide molecules have been successfully fabricated and explored their potential application for scavenging the carbonyl species in vitro. These macromolecules were dextrans with different hydrazide substitution ratios determined by TNBS assay, NMR and FTIR characterization.
Bo, Zhou +8 more
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Journal of Biomolecular NMR, 1997
Recently, a quantitative J correlation technique has been presented that permits measurement of 3Jc'c' in proteins isotopically enriched with 13C [Hu, J.-S. and Bax, A. (1996) J. Am. Chem. Soc., 118, 8170-8171]. Here, we describe an analogous experiment that is less sensitive to transverse 13C' relaxation, which is the principal limiting factor in all ...
Grzesiek, S., Bax, A.
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Recently, a quantitative J correlation technique has been presented that permits measurement of 3Jc'c' in proteins isotopically enriched with 13C [Hu, J.-S. and Bax, A. (1996) J. Am. Chem. Soc., 118, 8170-8171]. Here, we describe an analogous experiment that is less sensitive to transverse 13C' relaxation, which is the principal limiting factor in all ...
Grzesiek, S., Bax, A.
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Carbonyl-Amine Reactions in Protein Chemistry
1975Publisher Summary Reaction of a carbonyl group with an amino group is the key reaction in many enzymic and other biological processes, such as vision. This chapter discusses and attempts to organize and correlate the different types of carbonyl–amine reactions found in proteins with their organic chemistry.
R E, Feeney, G, Blankenhorn, H B, Dixon
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Interplay between protein carbonylation and nitrosylation in plants
PROTEOMICS, 2012ROS and reactive nitrogen species (RNS) are key regulators of redox homeostasis in living organisms including plants. As control of redox homeostasis plays a central function in plant biology, redox proteomics could help in characterizing the potential roles played by ROS/RNS‐induced posttranslational modification in plant cells ...
Lounifi, Imen +5 more
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Protein carbonyls in meat systems: A review
Meat Science, 2011Protein oxidation (P-OX) is an innovative topic of increasing interest among meat researchers. Carbonylation is generally recognized as one of the most remarkable chemical modifications in oxidized proteins. In fact, the quantification of protein carbonyls by the dinitrophenylhydrazine (DNPH) method is the most common procedure for assessing P-OX in ...
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Microfluidic Carbonylated Protein Capture
2013We report a proof of principle study for the use of oxalyldihydrazide as a crosslinker for enrichment of carbonylated proteins within a microfluidic chip. Surface modification steps are characterized and analyzed using analytical techniques. We use in vitro oxidized bovine serum albumin as a model protein for testing the selectivity and specificity of ...
Bryant C. Hollins +2 more
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Effects of carbonylation on the stability of proteins
2009Proteins frequently become irreversibly modified by carbonylation, a process of introducing the carbonyl group in a reaction with reactive oxygen species (ROS) such as superoxide, peroxide or ozone. Carbonylation increases with the age of cell and is associated with ageing and age related disorders such as Alzheimer's disease, Parkinson's disease and ...
Petrov, Dražen +2 more
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Fluoroquinolone antibiotics and organophosphate pesticides induce carbonylation on muscle proteins
Science of the Total Environment, 2021Johana Márquez-Lázaro +2 more
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