Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice. [PDF]
Petersen DR +7 more
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Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination. [PDF]
Irani DN.
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Anti-diabetic study of vitamin B6 on hyperglycaemia induced protein carbonylation, DNA damage and ROS production in alloxan induced diabetic rats. [PDF]
Abdullah KM +3 more
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Myofilament carbonylation modulates contractility in human cardiomyocytes [PDF]
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Dietary essential oils modulate post-mortem oxidative damage in trout fillets exposed to slaughter stress during frozen storage. [PDF]
Méndez L +5 more
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Not Aging but Calorie Restriction Strongly Affects Protein Oxidation in Heart and Brain Mitochondria. [PDF]
Fan S +7 more
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Emodin, a Phytotherapeutic Anthraquinone, Potently Attenuates Synaptic Redox Pathology in Aged Rats. [PDF]
Saha P, Ahmad F.
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Antioxidative and chaperone-like activities of a bacterioruberin-rich extract: An innovative approach to protect the skin proteome. [PDF]
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Protein carbonylation in human diseases
Trends in Molecular Medicine, 2003Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease,
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Protein carbonylation is a posttranslational modification referring to the occurrence of aldehydes and ketones in proteins. The current understanding of how carbonylation, in particular, metal-catalyzed carbonylation, occurs in recombinant mAbs during ...
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