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Protein conformation and biomolecular condensates [PDF]
Current Research in Structural Biology, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez +3 more
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eLife, 2021 Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic understanding of numerous key biological processes.
Nadia Füllbrunn +11 more
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Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits
Frontiers in Physiology, 2022 Striated muscle contraction and relaxation is regulated by Ca2+ at the myofilament level via conformational modulations of the troponin complex. To understand the structure–function relationship of troponin in normal muscle and in myopathies, it is ...
Monica Rasmussen +2 more
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Frontiers in Toxicology, 2023 Cerium oxide (CeO2) nanoparticles are expected to have applications in the biomedical field because of their antioxidative properties. Inorganic nanoparticles interact with proteins at the nanoparticle surface and change their conformation when ...
Masakazu Umezawa +4 more
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Pathogens, 2021 Amyloid structures assemble through a repeating type of bonding called “cross-β”, in which identical sequences in many protein molecules form β-sheets that interdigitate through side chain interactions.
Peter N. Lipke +3 more
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Frontiers in Molecular Neuroscience, 2022 Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui +5 more
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Biomolecules, 2019 De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui +3 more
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Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
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Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology, 2023 Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang +6 more
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Aβ Secretion and Plaque Formation Depend on Autophagy
Cell Reports, 2013 Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To
Per Nilsson +9 more
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