Results 1 to 10 of about 6,420,371 (402)

Protein conformation and biomolecular condensates [PDF]

open access: yesCurrent Research in Structural Biology, 2022
Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez   +3 more
doaj   +4 more sources

Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]

open access: yesBiochemistry, 2020
The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Kumar A, Narayanan V, Sekhar A.
europepmc   +2 more sources

Cooperative Gating and Spatial Organization of Membrane Proteins through Elastic Interactions [PDF]

open access: yes, 2007
Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium conformation via their local deformations, and spatially organize the proteins based on their geometry.
Andrej Sali   +4 more
arxiv   +12 more sources

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. [PDF]

open access: yesNucleic Acids Res, 2018
Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the ...
Rodrigues CH, Pires DE, Ascher DB.
europepmc   +2 more sources

Protein Conformation Generation via Force-Guided SE(3) Diffusion Models [PDF]

open access: yesarXiv
The conformational landscape of proteins is crucial to understanding their functionality in complex biological processes. Traditional physics-based computational methods, such as molecular dynamics (MD) simulations, suffer from rare event sampling and long equilibration time problems, hindering their applications in general protein systems.
Yan Wang   +6 more
arxiv   +2 more sources

Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. [PDF]

open access: yesChemistry, 2017
Fluorescence-based techniques are widely used to study biomolecular conformations, intra- and intermolecular interactions, and conformational dynamics of macromolecules.
Sánchez-Rico C   +4 more
europepmc   +2 more sources

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation. [PDF]

open access: yesProc Natl Acad Sci U S A, 2017
Significance The findings in this manuscript report on the identification of a posttranslational modification in the huntingtin protein (phosphorylation on residue T3 in the N17 region of the protein), which can revert the conformational effects of the ...
Cariulo C   +16 more
europepmc   +2 more sources

Pyrene: A Probe to Study Protein Conformation and Conformational Changes [PDF]

open access: yesMolecules, 2011
The review focuses on the unique spectral features of pyrene that can be utilized to investigate protein structure and conformation. Pyrene is a fluorescent probe that can be attached covalently to protein side chains, such as sulfhydryl groups.
Gursharan K Bains   +2 more
semanticscholar   +5 more sources

Protein conformation in a vaccine matters. [PDF]

open access: yesOncotarget, 2015
Vaccination is one of the most successful public health measures for control of viral diseases. Indeed, vaccines have either eliminated or considerably reduced many viral diseases worldwide. However, there are still many serious viral pathogens for which no vaccine is available. One of these pathogens is respiratory syncytial virus (RSV).
Morrison TG.
europepmc   +4 more sources

Home - About - Disclaimer - Privacy