Protein conformation and biomolecular condensates. [PDF]
Curr Res Struct Biol, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Vazquez DS +3 more
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Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]
Biochemistry, 2020 The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Kumar A, Narayanan V, Sekhar A.
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Cooperative Gating and Spatial Organization of Membrane Proteins through Elastic Interactions [PDF]
, 2007 Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium conformation ...
Andrej Sali +4 more
core +10 more sources
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. [PDF]
Nucleic Acids Res, 2018 Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the ...
Rodrigues CH, Pires DE, Ascher DB.
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Protein Conformation Generation via Force-Guided SE(3) Diffusion Models [PDF]
arXivThe conformational landscape of proteins is crucial to understanding their functionality in complex biological processes. Traditional physics-based computational methods, such as molecular dynamics (MD) simulations, suffer from rare event sampling and ...
Yan Wang +6 more
semanticscholar +2 more sources
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. [PDF]
Chemistry, 2017 Fluorescence-based techniques are widely used to study biomolecular conformations, intra- and intermolecular interactions, and conformational dynamics of macromolecules.
Sánchez-Rico C +4 more
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance The findings in this manuscript report on the identification of a posttranslational modification in the huntingtin protein (phosphorylation on residue T3 in the N17 region of the protein), which can revert the conformational effects of the ...
Cariulo C +16 more
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Pyrene: A Probe to Study Protein Conformation and Conformational Changes [PDF]
Molecules, 2011 The review focuses on the unique spectral features of pyrene that can be utilized to investigate protein structure and conformation. Pyrene is a fluorescent probe that can be attached covalently to protein side chains, such as sulfhydryl groups.
Gursharan K Bains +2 more
semanticscholar +5 more sources
The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV. [PDF]
Hum Vaccin Immunother, 2017 Respiratory syncytial virus (RSV) is a significant respiratory pathogen but no vaccine is available. RSV infections present 2 major, unique problems. First, humans can experience repeated infections caused by the same virus sero-group indicating that ...
Cullen LM, Schmidt MR, Morrison TG.
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