N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease. [PDF]
BiomoleculesGlycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules.
Pasala C +5 more
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Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]
Biochemistry, 2020 The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Kumar A, Narayanan V, Sekhar A.
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Protein conformation and biomolecular condensates. [PDF]
Curr Res Struct Biol, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts. An avalanche of studies highlighted the central role of biomolecular condensates in membraneless subcellular ...
Vazquez DS +3 more
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DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. [PDF]
Nucleic Acids Res, 2018 Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the ...
Rodrigues CH, Pires DE, Ascher DB.
europepmc +2 more sources
Steric exclusion and protein conformation determine the localization of plasma membrane transporters. [PDF]
Nat Commun, 2018 The plasma membrane (PM) of Saccharomyces cerevisiae contains membrane compartments, MCC/eisosomes and MCPs, named after the protein residents Can1 and Pma1, respectively. Using high-resolution fluorescence microscopy techniques we show that Can1 and the
Bianchi F +9 more
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Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation. [PDF]
Sci Rep, 2018 A congeneric series of 21 phosphodiesterase 2 (PDE2) inhibitors are reported. Crystal structures show how the molecules can occupy a ‘top-pocket’ of the active site.
Pérez-Benito L +3 more
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Pyrene: A Probe to Study Protein Conformation and Conformational Changes [PDF]
Molecules, 2011 The review focuses on the unique spectral features of pyrene that can be utilized to investigate protein structure and conformation. Pyrene is a fluorescent probe that can be attached covalently to protein side chains, such as sulfhydryl groups.
Gursharan K Bains +2 more
semanticscholar +5 more sources
Protein conformation in a vaccine matters. [PDF]
Oncotarget, 2015 Vaccination is one of the most successful public health measures for control of viral diseases. Indeed, vaccines have either eliminated or considerably reduced many viral diseases worldwide. However, there are still many serious viral pathogens for which no vaccine is available. One of these pathogens is respiratory syncytial virus (RSV).
Morrison TG.
europepmc +4 more sources
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. [PDF]
Chemistry, 2017 Sánchez-Rico C +4 more
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Probe protein conformation [PDF]
Nature Nanotechnology, 2018 Wenjie Sun
semanticscholar +3 more sources