Protein conformation and biomolecular condensates [PDF]
Current Research in Structural Biology, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez +3 more
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Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris. [PDF]
Microb Cell Fact, 2021 Background Protein synthesis is one of the extremely important anabolic pathways in the yeast expression system Pichia pastoris . Codon optimization is a commonly adopted strategy for improved protein expression, although unexpected failures did appear ...
Xu Y +6 more
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N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease. [PDF]
BiomoleculesGlycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules.
Pasala C +5 more
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Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]
Biochemistry, 2020 The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Kumar A, Narayanan V, Sekhar A.
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DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. [PDF]
Nucleic Acids Res, 2018 Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the ...
Rodrigues CH, Pires DE, Ascher DB.
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Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation. [PDF]
Sci Rep, 2018 A congeneric series of 21 phosphodiesterase 2 (PDE2) inhibitors are reported. Crystal structures show how the molecules can occupy a ‘top-pocket’ of the active site.
Pérez-Benito L +3 more
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Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. [PDF]
Chemistry, 2017 Sánchez-Rico C +4 more
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Frontiers in Molecular Neuroscience, 2022 Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui +5 more
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Frontiers in Toxicology, 2023 Cerium oxide (CeO2) nanoparticles are expected to have applications in the biomedical field because of their antioxidative properties. Inorganic nanoparticles interact with proteins at the nanoparticle surface and change their conformation when ...
Masakazu Umezawa +4 more
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Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase
Medicine in Drug Discovery, 2020 Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan +7 more
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