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Protein conformation and biomolecular condensates [PDF]
Current Research in Structural Biology, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez +3 more
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Frontiers in Molecular Neuroscience, 2022 Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui +5 more
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Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase
Medicine in Drug Discovery, 2020 Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan +7 more
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Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology, 2023 Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang +6 more
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eLife, 2021 Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic understanding of numerous key biological processes.
Nadia Füllbrunn +11 more
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Biosurface and Biotribology, 2022 Understanding material‐protein interactions is the basis for regulating material‐blood interactions, which is a common topic of interest for medical material developers.
Xiao Chen, Jiang Chen, Nan Huang
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Biomolecules, 2019 De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui +3 more
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Frontiers in Cell and Developmental Biology, 2020 Owing to the wide application of miniature pigs in biomedicine, the formation mechanism of its short stature must be elucidated. The insulin-like growth factor 1 receptor (IGF-1R), which receives signals through the extracellular domain (ECD) binding ...
Chunli Wang +10 more
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Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits
Frontiers in Physiology, 2022 Striated muscle contraction and relaxation is regulated by Ca2+ at the myofilament level via conformational modulations of the troponin complex. To understand the structure–function relationship of troponin in normal muscle and in myopathies, it is ...
Monica Rasmussen +2 more
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Genome-wide Translation Profiling by Ribosome-Bound tRNA Capture
Cell Reports, 2018 Summary: In the ribosome complex, tRNA is a critical element of mRNA translation. A rich repertoire of cell regulation is hypothesized to occur during the recruitment of specific tRNAs in polypeptide formation.
Chien-Wen Chen, Motomasa Tanaka
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