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Protein conformation and biomolecular condensates [PDF]

open access: yesCurrent Research in Structural Biology, 2022
Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez   +3 more
doaj   +4 more sources

Protein conformation in a vaccine matters. [PDF]

open access: yesOncotarget, 2015
Vaccination is one of the most successful public health measures for control of viral diseases. Indeed, vaccines have either eliminated or considerably reduced many viral diseases worldwide. However, there are still many serious viral pathogens for which no vaccine is available. One of these pathogens is respiratory syncytial virus (RSV).
Morrison TG.
europepmc   +4 more sources

Exploring the conformational diversity of proteins [PDF]

open access: yeseLife, 2022
An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.
Avner Schlessinger, Massimiliano Bonomi
openaire   +4 more sources

Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits

open access: yesFrontiers in Physiology, 2022
Striated muscle contraction and relaxation is regulated by Ca2+ at the myofilament level via conformational modulations of the troponin complex. To understand the structure–function relationship of troponin in normal muscle and in myopathies, it is ...
Monica Rasmussen   +2 more
doaj   +1 more source

Conformations of Proteins in Equilibrium [PDF]

open access: yesPhysical Review Letters, 2001
6 pages, 3 eps ...
Micheletti, Cristian   +2 more
openaire   +4 more sources

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

open access: yeseLife, 2021
Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic understanding of numerous key biological processes.
Nadia Füllbrunn   +11 more
doaj   +1 more source

A New Function for Amyloid-Like Interactions: Cross-Beta Aggregates of Adhesins form Cell-to-Cell Bonds

open access: yesPathogens, 2021
Amyloid structures assemble through a repeating type of bonding called “cross-β”, in which identical sequences in many protein molecules form β-sheets that interdigitate through side chain interactions.
Peter N. Lipke   +3 more
doaj   +1 more source

Infrared spectroscopy analysis determining secondary structure change in albumin by cerium oxide nanoparticles

open access: yesFrontiers in Toxicology, 2023
Cerium oxide (CeO2) nanoparticles are expected to have applications in the biomedical field because of their antioxidative properties. Inorganic nanoparticles interact with proteins at the nanoparticle surface and change their conformation when ...
Masakazu Umezawa   +4 more
doaj   +1 more source

How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders

open access: yesFrontiers in Molecular Neuroscience, 2022
Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui   +5 more
doaj   +1 more source

Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances

open access: yesBiomolecules, 2019
De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui   +3 more
doaj   +1 more source

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