Results 1 to 10 of about 706,028 (296)

Protein conformation and biomolecular condensates [PDF]

Current Research in Structural Biology, 2022
Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez, Pamela L. Toledo, Alejo R. Gianotti, Mario R. Ermácora   +3 more
doaj   +2 more sources

How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders

Frontiers in Molecular Neuroscience, 2022
Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui, Kelvin K. Hui, Thomas E. Chater, Yukiko Goda, Yukiko Goda, Motomasa Tanaka   +5 more
doaj   +1 more source

Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

Medicine in Drug Discovery, 2020
Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan, Neha Gupta, Qudsia Rashid, Irshad Ahmad, Shadabi Bano, Urfi Siddiqui, Mohammad Abid, Mohamad Aman Jairajpuri   +7 more
doaj   +1 more source

Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura

Hematology, 2023
Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou   +6 more
doaj   +1 more source

Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function

Life Science Alliance, 2023
Deep mutational interaction perturbation scanning of NF2 with conformation-dependent interaction partners KDM1A, EMILIN, and PIK3R3 revealed two regions critical for NF2 tumor suppressor function. NF2 (moesin–ezrin–radixin-like [MERLIN] tumor suppressor)
Christina S Moesslacher, Elisabeth Auernig, Jonathan Woodsmith, Andreas Feichtner, Evelyne Jany-Luig, Stefanie Jehle, Josephine M Worseck, Christian L Heine, Eduard Stefan, Ulrich Stelzl   +9 more
doaj   +1 more source

The structure, formation, and effect of plasma protein layer on the blood contact materials: A review

Biosurface and Biotribology, 2022
Understanding material‐protein interactions is the basis for regulating material‐blood interactions, which is a common topic of interest for medical material developers.
Xiao Chen, Jiang Chen, Nan Huang
doaj   +1 more source

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

eLife, 2021
Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic understanding of numerous key biological processes.
Nadia Füllbrunn, Zehao Li, Lara Jorde, Christian P Richter, Rainer Kurre, Lars Langemeyer, Changyuan Yu, Carola Meyer, Jörg Enderlein, Christian Ungermann, Jacob Piehler, Changjiang You   +11 more
doaj   +1 more source

Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances

Biomolecules, 2019
De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui, Yi-Kai Chen, Ryo Endo, Motomasa Tanaka   +3 more
doaj   +1 more source

Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells

Frontiers in Cell and Developmental Biology, 2020
Owing to the wide application of miniature pigs in biomedicine, the formation mechanism of its short stature must be elucidated. The insulin-like growth factor 1 receptor (IGF-1R), which receives signals through the extracellular domain (ECD) binding ...
Chunli Wang, Siyao Wang, Songcai Liu, Yunyun Cheng, Hongwei Geng, Rui Yang, Tianqi Feng, Guanhong Lu, Xiaotong Sun, Jie Song, Linlin Hao   +10 more
doaj   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources