Results 11 to 20 of about 3,930,063 (310)

Protein conformation and biomolecular condensates [PDF]

Current Research in Structural Biology, 2022
Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts.
Diego S. Vazquez, Pamela L. Toledo, Alejo R. Gianotti, Mario R. Ermácora   +3 more
doaj   +4 more sources

Conformations of Proteins in Equilibrium [PDF]

Physical Review Letters, 2001
6 pages, 3 eps ...
Micheletti, Cristian, J. R. BANAVAR, A. MARITAN   +2 more
openaire   +4 more sources

How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders

Frontiers in Molecular Neuroscience, 2022
Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui, Kelvin K. Hui, Thomas E. Chater, Yukiko Goda, Yukiko Goda, Motomasa Tanaka   +5 more
doaj   +1 more source

Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

Medicine in Drug Discovery, 2020
Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan, Neha Gupta, Qudsia Rashid, Irshad Ahmad, Shadabi Bano, Urfi Siddiqui, Mohammad Abid, Mohamad Aman Jairajpuri   +7 more
doaj   +1 more source

Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura

Hematology, 2023
Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou   +6 more
doaj   +1 more source

Protein-Ligand Interactions: Docking, Design and Conformation Change [PDF]

, 2003
Virtual ligand screening has proven to be a successful strategy in drug design. An in house-developed procedure (HierDock), a coarse grain docking method followed by a fine grain search procedure, was used to determine the binding site for sugars in the
Datta, Deepshikha
core   +1 more source

Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances

Biomolecules, 2019
De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui, Yi-Kai Chen, Ryo Endo, Motomasa Tanaka   +3 more
doaj   +1 more source

The structure, formation, and effect of plasma protein layer on the blood contact materials: A review

Biosurface and Biotribology, 2022
Understanding material‐protein interactions is the basis for regulating material‐blood interactions, which is a common topic of interest for medical material developers.
Xiao Chen, Jiang Chen, Nan Huang
doaj   +1 more source

Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function

Life Science Alliance, 2023
Deep mutational interaction perturbation scanning of NF2 with conformation-dependent interaction partners KDM1A, EMILIN, and PIK3R3 revealed two regions critical for NF2 tumor suppressor function. NF2 (moesin–ezrin–radixin-like [MERLIN] tumor suppressor)
Christina S Moesslacher, Elisabeth Auernig, Jonathan Woodsmith, Andreas Feichtner, Evelyne Jany-Luig, Stefanie Jehle, Josephine M Worseck, Christian L Heine, Eduard Stefan, Ulrich Stelzl   +9 more
doaj   +1 more source

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]

, 2010
The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina, Watt, Carolyn, McEwan, Iain Joseph, Nicholas C. Price, Kelly, S.M., Katharina Fischer, Price, N.C., McEwan, I. J., Watt, K., Fischer, K., Price, Nicholas C., Sharon M. Kelly, Kate Watt, Iain J. McEwan, Kelly, Sharon M.   +14 more
core   +1 more source