Results 11 to 20 of about 103,093 (251)
Toxins, 2022 VVA2 (volvatoxin A chain 2) is a cardiotoxic protein purified from Volvariella volvacea. Its biological activities include hemolysis, writhing reaction, neurotoxicity, and ventricular systolic arresting activity.
Jia-Qi Lu +5 more
doaj +1 more source
A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein
Toxins, 2022 Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects.
Jia-Qi Lu, Kam-Bo Wong, Pang-Chui Shaw
doaj +1 more source
Scientific Reports, 2022 Evidence is mounting that the nature of the lipid bound to the endothelial cell protein C receptor (EPCR) has an impact on its biological roles, as observed in anticoagulation and more recently, in autoimmune disease.
Elena Erausquin +6 more
doaj +1 more source
Abstract P-13: Cryo-ET Structural Analysis of Polyribosomes from HeLa Cells [PDF]
International Journal of Biomedicine, 2019 Background: Polyribosomes are complexes consisting of several ribosomes simultaneously translating a single mRNA molecule. In early electron microscopy studies, it was shown that eukaryotic polyribosomes in cells can have various shapes – rings, double ...
Zhanna A. Afonina +5 more
doaj +1 more source
Databases in Protein Crystallography [PDF]
Acta Crystallographica Section D Biological Crystallography, 1998 Applications of structural databases in the protein crystallographic structure determination process are reviewed, using mostly examples from work carried out by the authors. Four application areas are discussed: model building, model refinement, model validation and model analysis.
G J, Kleywegt, T A, Jones
openaire +2 more sources
Toxins, 2016 Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits protein synthesis by depurinating the N-glycosidic bond at α-sarcin/ricin loop (SRL) of the 28S rRNA, which thereby prevents the ...
Wei-Wei Shi +5 more
doaj +1 more source
IUCrJ, 2017 The Protein Crystallography Station (PCS), located at the Los Alamos Neutron Scattering Center (LANSCE), was the first macromolecular crystallography beamline to be built at a spallation neutron source.
Julian C.-H. Chen, Clifford J. Unkefer
doaj +1 more source
Communications Biology, 2022 The cytosolic tail of β-coronavirus spike proteins contains dibasic motifs that must be able to bind to the host’s coatomer protein-I (COPI) for trafficking and be released for viral assembly in the ER-Golgi intermediate compartment.
Debajit Dey +7 more
doaj +1 more source
Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
doaj +1 more source
Abstract P-14: Cryo-Electron Tomography Pipeline on the Example of Structural Analysis of Polyribosomes [PDF]
International Journal of Biomedicine, 2019 Background: Cryo-electron tomography (cryo-ET) is currently the only technique that can be used for quaternary structure determination of polyribosomal complexes under near physiological conditions.
Timur N. Baymukhametov +3 more
doaj +1 more source