Results 21 to 30 of about 103,093 (251)
Small-angle neutron scattering studies suggest the mechanism of BinAB protein internalization
IUCrJ, 2020 Small-angle neutron scattering (SANS) is one of the most widely used neutron-based approaches to study the solution structure of biological macromolecular systems.
Mahima Sharma +3 more
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Study of the Interaction of Sorption and Catalytic Centers in Carboxypeptidase T by X-ray Analysis
Crystals, 2021 Carboxypeptidase T (CPT; EC 3.4.17.18) from Thermoactinomyces vulgaris is a distant homolog of the highly specific pancreatic carboxypeptidase B; but has a broad substrate specificity; the source of which remains unclear.
Valerij Akparov +3 more
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Macromolecular neutron crystallography at the Protein Crystallography Station (PCS) [PDF]
Acta Crystallographica Section D Biological Crystallography, 2010 The Protein Crystallography Station (PCS) at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. Neutron diffraction is a powerful technique for locating H atoms and can therefore provide unique information about how biological ...
Andrey, Kovalevsky +5 more
openaire +2 more sources
Toxins, 2018 Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
doaj +1 more source
Cell & Bioscience, 2019 Background Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres.
Sai-Tim Ho +4 more
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Protein Crystallography: Achievements and Challenges
Crystals, 2023 Proteins are the most important biological macromolecules, and are involved in almost all aspects of life. Therefore, the study of the structure of proteins is of great practical and fundamental importance.
Vladimir Timofeev, Valeriya Samygina
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Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro
Biology DirectBackground SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and immune evasion. It contains an N-terminal ubiquitin-like (Ubl) domain, whose involvement in enzymatic function remains poorly understood.
Rimanshee Arya +3 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Severe deviation in protein fold prediction by advanced AI: a case study
Scientific ReportsArtificial intelligence (AI) and deep learning are making groundbreaking strides in protein structure prediction. AlphaFold is remarkable in this arena for its outstanding accuracy in modelling proteins fold based solely on their amino acid sequences. In
Jacinto López-Sagaseta +1 more
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