Results 41 to 50 of about 103,093 (251)

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

mBio, 2014
Response regulators are proteins that undergo transient phosphorylation, connecting specific signals to adaptive responses. Remarkably, the molecular mechanism of response regulator activation remains elusive, largely because of the scarcity of ...
Felipe Trajtenberg, Daniela Albanesi, Natalia Ruétalo, Horacio Botti, Ariel E. Mechaly, Marcos Nieves, Pablo S. Aguilar, Larisa Cybulski, Nicole Larrieux, Diego de Mendoza, Alejandro Buschiazzo   +10 more
doaj   +1 more source

The Anisotropic Adsorption of De Novo Allosteric Two‐Component Protein Fibers on Mica Surfaces

Advanced Functional Materials, EarlyView.
In this study, the interfacial behavior of de novo designed proteins that self‐assemble into tubular architectures with distinct morphologies — small (S), large (L), and helical (H) fibers — at the muscovite mica‐water interface is explored using in situ AFM. Abstract Protein adsorption at solid–liquid interfaces underlies many biomedical and materials
Chenyang Shi, Hao Shen, Yuna Bae, Jaeyoung Heo, Shuai Zhang, Lehan Yao, David Baker, James J De Yoreo   +7 more
wiley   +1 more source

Electron–Matter Interactions During Electron Beam Nanopatterning

Advanced Functional Materials, EarlyView.
This article reviews the electron–matter interactions important to nanopatterning with electron beam lithography (EBL). Electron–matter interactions, including secondary electron generation routes, polymer radiolysis, and electron beam induced charging, are discussed.
Camila Faccini de Lima, Prathiba Thamizhavel, Taylor J. Woehl   +2 more
wiley   +1 more source

Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation

Toxins, 2016
To improve the pharmacological properties of maize ribosome-inactivating protein (maize RIP) for targeting HIV-infected cells, the previously engineered TAT-fused active form of maize RIP (MOD) was further engineered for cysteine-directed PEGylation.
Ka-Yee Au, Wei-Wei Shi, Shuai Qian, Zhong Zuo, Pang-Chui Shaw   +4 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Protein crystallography and infectious diseases [PDF]

Protein Science, 1994
AbstractThe current rapid growth in the number of known 3‐dimensional protein structures is producing a database of structures that is increasingly useful as a starting point for the development of new medically relevant molecules such as drugs, therapeutic proteins, and vaccines.
C L, Verlinde, E A, Merritt, F, Van den Akker, H, Kim, I, Feil, L F, Delboni, S C, Mande, S, Sarfaty, P H, Petra, W G, Hol   +9 more
openaire   +2 more sources

New insights into structural and functional relationships between LonA proteases and ClpB chaperones

FEBS Open Bio, 2019
LonA proteases and ClpB chaperones are key components of the protein quality control system in bacterial cells. LonA proteases form a unique family of ATPases associated with diverse cellular activities (AAA+) proteins due to the presence of an unusual N‐
Tatyana V. Rotanova, Anna G. Andrianova, Arsen M. Kudzhaev, Mi Li, Istvan Botos, Alexander Wlodawer, Alla Gustchina   +6 more
doaj   +1 more source

Unravelling the Atomic Structure of a Metal‐Covalent Organic Framework Assembled from Ruthenium Metalloligands

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Metal‐covalent organic frameworks (MCOFs) are novel porous materials that exhibit the advantages of covalent and metal‐organic frameworks. However, it is extremely difficult to resolve their atomic structure and better understand their structure‐properties relation. This work utilizes a synergistic combination of advanced microscopy, spectroscopic, and
Seán Hennessey, Roberto González‐Gómez, Nicolás Arisnabarreta, Anna Ciotti, Jing Hou, Nadezda V. Tarakina, Andrey Bezrukov, Kunal S. Mali, Michael Zaworotko, Steven De Feyter, Max García‐Melchor, Pau Farràs   +11 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Triiodide derivatization in protein crystallography [PDF]

Acta Crystallographica Section D Biological Crystallography, 2003
Methods for producing protein derivatives using cryosoak techniques with triiodide solutions are described. The methods have been tested using six different proteins. SAD/SIRAS phasing was attempted for each protein using data measured with conventional Cu Kα X-ray equipment and synchrotron radiation.
Gwyndaf, Evans, Gérard, Bricogne
openaire   +2 more sources