Results 251 to 260 of about 542,906 (295)

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

<i>OncoSolidDB</i>: An Oncology-Focused Curated Database of Ligand-Target Interactions for Precision Medicine Across Major Solid Cancers. [PDF]

Cancers (Basel)
Khamessi O, Mahjoub R, Mahjoub G, Ghedira K.   +3 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Exploring the global mosaic of medicinal plant databases: unveiling nature's pharmacopoeia. [PDF]

Nat Prod Bioprospect
Jiang Y, Jia X, Yang Z.
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks. [PDF]

Proc Natl Acad Sci U S A
Saha A, Tang CL, Murray D, Honig B.
europepmc   +1 more source

Multi-scale analysis reveals key targets mediating BPA-induced sensorineural hearing loss. [PDF]

Medicine (Baltimore)
Yan X, Xuan J, Peng J.
europepmc   +1 more source

iCRCexp: An Integrative Database for Colorectal Cancer-Associated Gene Expression Profiles. [PDF]

Cancer Inform
Yuan Y, Cao BJ, Qian ZK, Liu ZK, Xiao WW, Li XY, Zuo ZX, Liu ZX, Gao YH.   +8 more
europepmc   +1 more source

Development and Validation of an Algorithm for Constructing an Amino Acid Database for Application to the Korean Genome and Epidemiology Study Cohort. [PDF]

Nutrients
Lee SJ, Hwang JY.
europepmc   +1 more source

A perspective and demonstration of an approach to screening synthetic nucleic acid orders containing short nucleic acid sequences. [PDF]

Front Bioeng Biotechnol
Gemler BT, Flyangolts K, Diggans J, Wittmann BJ, Fullerton PA, Seltzer MJ, Bartling C.   +6 more
europepmc   +1 more source