Results 181 to 190 of about 8,887,267 (401)

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking [PDF]

, 2012
Eleftherios Kostaras, George Sflomos, Nina Marie Pedersen, Harald Stenmark, Theodore Fotsis, Carol Murphy   +5 more
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer [PDF]

Irene Herranz-Montoya, Mariana Angulo-Aguado, Cristian Perna, Sladjana Zagorac, Luis García-Jimeno, Solip Park, Nabil Djouder   +6 more
openalex   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Two Pathways for Cyclooxygenase-2 Protein Degradation in Vivo [PDF]

, 2009
M. Wada, Thomas L. Saunders, Jason D. Morrow, Ginger L. Milne, Kimberly Walker, Sudhansu K. Dey, Thomas G. Brock, Mark R. Opp, David M. Aronoff, William L. Smith   +9 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Highly Specific Cytokine Receptor‐Targeting Chimeras for Targeted Membrane Protein Degradation and Sensitization of Osimertinib in EGFR‐Mutated Non‐Small‐Cell Lung Cancer [PDF]

Jiawei Wu, Qianqian Gao, Qing Xia, Yaru Wang, Zixuan Zheng, Axin He, Yang Liu, Yang Yang, Yanyan Miao, Da Han   +9 more
openalex   +1 more source

Altering Soluble and Potentially Rumen Degradable Protein for Prepubertal Holstein Heifers [PDF]

, 2003
M.T. Gabler, A.J. Heinrichs
openalex   +1 more source

Caleosin 1 contributes to seed lipid droplet degradation by interaction with autophagy-related protein ATG8 [PDF]

, 2023
Magdalena Miklaszewska, Krzysztof Zienkiewicz, Ewa Klugier-Borowska, Marcin Rygielski, Ivo Feußner, Agnieszka Zienkiewicz   +5 more
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source