Results 181 to 190 of about 1,856,978 (353)

Small-molecule degron mimetics for targeted protein degradation. [PDF]

Essays Biochem
Liu X.
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

A breakthrough in NSCLC therapy: targeted protein degradation of CD26 via PROTACs. [PDF]

EBioMedicine
Guan X, Yu XY, Zhang L.
europepmc   +1 more source

Archaeal protein biogenesis: posttranslational modification and degradation [PDF]

, 2010
Eichler, Jerry, Maupin-Furlow, Julie, Soppa, Jörg (Prof. Dr.)   +2 more
core  

Supporting Information: Figures from Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer

, 2023
Longchuan Bai, Bing Zhou, Chao‐Yie Yang, Jiao Ji, Donna McEachern, Sally Przybranowski, Hui Jiang, Jiantao Hu, Fuming Xu, Yu‐Jun Zhao, Liu Liu, Ester Fernández‐Salas, Jing Xu, Yali Dou, Bo Wen, Duxin Sun, Jennifer L. Meagher, Jeanne A. Stuckey, Daniel F. Hayes, Shunqiang Li, Matthew J. Ellis, Shaomeng Wang   +21 more
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

An Enigma of N-termini dependent protein degradation. [PDF]

Biochem Biophys Rep
Alhourani L, Elgohary AM, Fahlman RP.
europepmc   +1 more source

Data from Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

, 2023
George M. Burslem, Anna Reister Schultz, Daniel P. Bondeson, Christopher A. Eide, Samantha L. Savage, Brian Druker, Craig M. Crews   +6 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation. [PDF]

Int Dent J
Zhang R, Xiong M, Li B, Sheng L, Zhang B, Wang M, Liu J.   +6 more
europepmc   +1 more source