Results 31 to 40 of about 8,887,267 (401)

Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

Journal of Experimental & Clinical Cancer Research, 2017
Background Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract.
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu   +14 more
doaj   +1 more source

UPRmt and coordinated UPRER in type 2 diabetes

Frontiers in Cell and Developmental Biology, 2022
The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D).
Zhanfang Kang, Feng Chen, Wanhui Wu, Rui Liu, Tianda Chen, Fang Xu, Fang Xu   +6 more
doaj   +1 more source

Cezanne regulates E2F1-dependent HIF2α expression [PDF]

, 2015
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun, Bangoura, Baudino, Bento, Bett, Bremm, Bremm, Bremm, Budhavarapu, Chiavarina, Cox, Enesa, Fandrey, Fraile, Gordan, Gordan, Holmquist-Mengelbier, Hospenthal, Hu, Hubbi, Ivan, Jaakkola, Keith, Komander, Li, Li, Li, Linehan, Liu, Lukas, Luong, Matsumoto, Meyer, Neumann, Noguera, Pal, Pareja, Raval, Rius, Schumm, Scrideli, Semenza, Shen, Stevens, Troilo, van Uden, Wada, Webster, Yu   +48 more
core   +4 more sources

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

bioRxiv, 2021
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD).
Nathaniel J. Henning, A. Manford, Jessica N. Spradlin, S. Brittain, J. McKenna, John A. Tallarico, M. Schirle, M. Rapé, Daniel K. Nomura   +8 more
semanticscholar   +1 more source

Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]

, 2018
Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson, K Devaraj, Neal, M Cole, Christian, Shi, Xinying, Wu, Ti   +4 more
core   +2 more sources

Regulation of Protein Degradation [PDF]

The Plant Cell, 1995
of understanding of how to preserve in vivo proteolytic activities in vitro also has interfered with the identification, purification, and analyses of proteinases. Although studies using heterologous proteins or synthetic peptide substrates will continue to provide valuable information, such studies must at some point utilize in vivo substrates if the ...
openaire   +2 more sources

DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.

Journal of the American Chemical Society, 2021
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery.
Xiaoyu Zhang, Lena Luukkonen, Christie L. Eissler, Vincent M. Crowley, Yu Yamashita, Michael A. Schafroth, S. Kikuchi, D. Weinstein, K. Symons, B. Nordin, Joe L. Rodriguez, T. Wucherpfennig, L. Bauer, M. Dix, Dean P Stamos, T. Kinsella, G. Simon, K. Baltgalvis, B. Cravatt   +18 more
semanticscholar   +1 more source

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

Molecular Cancer, 2021
Background Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer initiation and progression.
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li   +14 more
doaj   +1 more source

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
doaj   +1 more source