Results 81 to 90 of about 1,745,513 (378)

Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy

Frontiers in Medicine, 2021
Background and Aim: Hepatic encephalopathy (HE) is a neurological disease caused by severe liver disease. Early identification of the risk factor is beneficial to the prevention and treatment of HE.
Yanling Li, Yanling Li, Huiyuan Liu, Keng Chen, Xueheng Wu, Jiawen Wu, Zhenjun Yang, Leyi Yao, Leyi Yao, Guanmei Wen, Change Zhang, Xin Chen, Xiaohui Chen, Daolin Tang, Xuejun Wang, Jinbao Liu, Jinbao Liu   +16 more
doaj   +1 more source

The known unknowns of the Hsp90 chaperone [PDF]

arXiv, 2023
Molecular chaperones are vital proteins that maintain protein homeostasis by assisting in protein folding, activation, degradation, and stress protection. Among them, heat-shock protein 90 (Hsp90) stands out as an essential proteostasis hub in eukaryotes, chaperoning hundreds of "clients" (substrates). After decades of research, several "known unknowns"
arxiv  

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system

Journal of Translational Medicine, 2022
Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the lipid-lowering and cardioprotective properties of bilirubin, as well as the negative relationship between ...
Guanmei Wen, Leyi Yao, Yali Hao, Jinheng Wang, Jinbao Liu   +4 more
doaj   +1 more source

Modeling PROTAC Degradation Activity with Machine Learning [PDF]

Artificial Intelligence in the Life Sciences, Volume 6, 2024, 100104
PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs is challenging and requires significant domain expertise, time, and cost. Meanwhile, machine learning has transformed drug design and development.
arxiv   +1 more source

Learning Unknown from Correlations: Graph Neural Network for Inter-novel-protein Interaction Prediction [PDF]

arXiv, 2021
The study of multi-type Protein-Protein Interaction (PPI) is fundamental for understanding biological processes from a systematic perspective and revealing disease mechanisms. Existing methods suffer from significant performance degradation when tested in unseen dataset. In this paper, we investigate the problem and find that it is mainly attributed to
arxiv  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

Signal Transduction and Targeted Therapy, 2023
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently needed. Here, a compound library consisting of 419 FDA-approved
Xiang-Peng Tan, Yan He, Jing Yang, Xian Wei, You-Long Fan, Guo-Geng Zhang, Yi-Dong Zhu, Zheng-Qiu Li, Hua-Xin Liao, Da-Jiang Qin, Xin-Yuan Guan, Bin Li   +11 more
doaj   +1 more source

Decomposing Noise in Biochemical Signaling Systems Highlights the Role of Protein Degradation [PDF]

, 2013
Stochasticity is an essential aspect of biochemical processes at the cellular level. We now know that living cells take advantage of stochasticity in some cases and counteract stochastic effects in others.
Ball, Bevis, Bray, Decker, Dong, El-Samad, Elf, Elowitz, Gadgil, Gillespie, Gur, Jacek Miękisz, Komorowski, Komorowski, Kurtz, Lestas, Levine, Michael P.H. Stumpf, Michał Komorowski, Ozbudak, Paszek, Paulsson, Pedraza, Pedraza, Rausenberger, Silva-Rocha, Tkacik, Tsien, van Kampen, Wallace   +29 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source