Results 301 to 310 of about 5,941,139 (381)

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation

open access: yesAdvanced Science, EarlyView.
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin   +6 more
wiley   +1 more source

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications

open access: yesAdvanced Science, EarlyView.
Lyophilization is a key process used in the production of biotherapeutic products. This article reviews and discusses the application of HSI on lyophilization, and the strategies that use the resulting data to build models. It is intended to provide guidance and insights for non‐specialist researchers and engineers into leveraging HSI and the data ...
Huiwen Yu   +5 more
wiley   +1 more source

A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
DNA gel bandage (DNAgb) is designed to precisely target the site of inflammation of IBD, by achieving dual specific localization of inflamed mucosa through electrostatic interactions and ApITGA4‐mediated affinity targeting. DNAgb effectively the activation of inflammatory pathways and reshapes the immune microenvironment.
Peifen Lu   +9 more
wiley   +1 more source

Molecular Aggregates of Wheat Starch–Protein Systems: Structural Disruption and Engineered Digestibility via Non‐Covalent Synergy

open access: yesAggregate, EarlyView.
This study combines molecular dynamics simulations and multi‐scale experiments to decode how wheat proteins (globulin, gliadin, and glutelin) form non‐covalent networks with starch, reducing structural order, and slowing enzymatic hydrolysis. These findings provide a blueprint for tailoring starch‐based foods with controlled glycemic response ...
Cuihong Dai   +4 more
wiley   +1 more source

In Situ Graph Reasoning and Knowledge Expansion Using Graph‐PRefLexOR

open access: yesAdvanced Intelligent Discovery, EarlyView.
Graph‐PRefLexOR is a novel framework that enhances language models with in situ graph reasoning, symbolic abstraction, and recursive refinement. By integrating graph‐based representations into generative tasks, the approach enables interpretable, multistep reasoning.
Markus J. Buehler
wiley   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone   +13 more
wiley   +1 more source

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