Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Introduction & Objective: Evaluation of the quality of food proteins have a great importance because of biological and economical impacts. Different biological, microbiological, chemical and combined methods have been used and introduced for determining
M Taghizade, Z Asemi
doaj
Nutritional quality of the protein of Vigna unguiculata L. Walp and its protein isolate
A protein's true digestibility and amino acid composition are important characteristics for its nutritional characterisation. This study determined the true digestibility of the protein from cowpea (Vigna unguiculata L. Walp.) and of its protein isolate,
Karoline de Macêdo Gonçalves Frota +3 more
doaj +1 more source
Penentuan Daya Cerna Protein In Vitro Ikan Bawal (Colossoma Macropomum) pada Umur Panen Berbeda
Digestibility is part of the sample consumed and not released into the feces. This study discusses about the protein digestibility of tambaqui fish (Colossoma macropomum) at different ages and sizes in vitro. Protein digestibility is the ability of ...
Dede Saputra
doaj +1 more source
The Effects of Different Energy and Protein Ratio to Goat’s Nutrient Intake and Digestibility
The objective of this research was to study the effects of different energy and protein ratio towards goat’s nutrient intake and digestibility. Twenty four male goats, 6 – 7 months old with initial average live weight 13+1.56 kg, coefficient variant11 ...
Agung, Purnomoadi +3 more
core
Response to dietary tannin challenges in view of the browser/grazer dichotomy in an Ethiopian setting : Bonga sheep versus Kaffa goats [PDF]
It has been suggested that goats (typical browser) are better adapted to digest tannin-rich diets than sheep (typical grazer). To evaluate this, Bonga sheep and Kaffa goats were used in a 2x3 randomized crossover design with two species, three diets, and
Janssens, Geert +4 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Blood addition and processing conditions: Improving protein content and digestibility value of hydrolyzed feather meal [PDF]
The study aimed to optimize the processing conditions for hydrolyzed feather meal (HFM) with the addition of coagulated blood. Factorial design and response surface methodology were used to optimize processing conditions in function of protein content (%)
Marcia Regina Sinhorini +5 more
doaj +1 more source
A note on the evaluation of the acid-insoluble ash technique as a method for determining apparent diet digestibility in beef cattle. [PDF]
peer-reviewedThe objective was to determine if the acid-insoluble ash (AIA) method provided accurate estimates of in vivo apparent digestibility compared with the standard total faecal collection (TFC) method.
Kenny, David A. +2 more
core
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source

