Results 111 to 120 of about 7,315 (215)

Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer. [PDF]

Antioxid Redox Signal, 2022
Jiang H, Thapa P, Hao Y, Ding N, Alshahrani A, Wei Q.   +5 more
europepmc   +1 more source

Oxidative protein folding in the mitochondrial intermembrane space [PDF]

, 2010
Disulfide bond formation is a crucial step for oxidative folding and necessary for the acquisition of a protein's native conformation. Introduction of disulfide bonds is catalyzed in specialized subcellular compartments and requires the coordinated ...
Anfinsen CB, Dionisia P. Sideris, Giorda R, Kamitani S, Kostas Tokatlidis   +4 more
core   +1 more source

Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction

Neurobiology of Disease
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by neuromuscular connectivity decline followed by motoneuron loss.
Martin Sepulveda, Francisca MartinezTraub, Patricia Ojeda, Jessica Mella, Jorge Ojeda, Cristina Pinto, Rodrigo Diaz, Pablo Rozas, Claudia Sepulveda, Bredford Kerr, Vania Morales, Mirva Saaranen, Lloyd Ruddock, Danilo B. Medinas, Juan Pablo Henriquez, Claudio Hetz   +15 more
doaj   +1 more source

Critical roles of protein disulfide isomerases in balancing proteostasis in the nervous system. [PDF]

J Biol Chem, 2022
Medinas DB, Rozas P, Hetz C.
europepmc   +1 more source

Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. [PDF]

Chem Res Toxicol, 2022
Freije BJ, Freije WM, Do TU, Adkins GE, Bruch A, Hurtig JE, Morano KA, Schaffrath R, West JD.   +8 more
europepmc   +1 more source

Selective Inhibition of Protein Disulfide Isomerase by Estrogens

Journal of Biological Chemistry, 1989
Protein disulfide isomerase (PDI) is a multifunctional microsomal enzyme that participates in the formation of protein disulfide bonds. PDI catalyzes the reduction of protein disulfide bonds in the presence of excess reduced glutathione and has been implicated in the reductive degradation of insulin; E.
J C, Tsibris, L T, Hunt, G, Ballejo, W C, Barker, L J, Toney, W N, Spellacy   +5 more
openaire   +2 more sources

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway. [PDF]

Autophagy, 2022
Wang B, Zhang J, Liu X, Chai Q, Lu X, Yao X, Yang Z, Sun L, Johnson SF, Schwartz RC, Zheng YH.   +10 more
europepmc   +1 more source

Molecular cloning and characterization of protein disulfide isomerase of Brugia malayi, a human lymphatic filarial parasite [PDF]

Lymphatic filariasis results in an altered lymphatic system and the abnormal enlargement of body parts, causing pain, serious disability and social stigma.
Doharey, Pawan Kumar, Omer, Ankur, Saxena, Jitendra Kumar, Singh, Poonam, Verma, Pravesh, Yadav, Sunita   +5 more
core   +1 more source

Protein disulfide isomerase-9 interacts with the lumenal region of the transmembrane endoplasmic reticulum stress sensor kinase, IRE1, to modulate the unfolded protein response in Arabidopsis

Frontiers in Plant Science
Environmental stressors disrupt secretory protein folding and proteostasis in the endoplasmic reticulum (ER), leading to ER stress. The unfolded protein response (UPR) senses ER stress and restores proteostasis by increasing the expression of ER-resident
Rina Carrillo, Kaela Iwai, Alena Albertson, Gabrielle Dang, David A. Christopher   +4 more
doaj   +1 more source