Results 131 to 140 of about 3,285 (194)

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

eLife
Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams, Ryan J Paxman, William E Balch, Jeffery W Kelly, Tingwei Mu, R Luke Wiseman   +10 more
doaj   +1 more source

Enzymatic dyeing of keratinous materials [PDF]

, 2003
Poster apresentado no "Biotrans Olomouc 2003 - 6th International Symposium on Biocatalysis and Biotransformations", em Olomouc, Czech Republic, 2003This study reports on the dyeing of keratinous materials using appropriate enzymatic systems – laccases ...
Paulo, Artur Cavaco, Prada, Enrique, Silva, Carla J. S. M., Tzanov, Tzanko, Zille, Andrea   +4 more
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Molecular cloning and characterization of protein disulfide isomerase of Brugia malayi, a human lymphatic filarial parasite [PDF]

Lymphatic filariasis results in an altered lymphatic system and the abnormal enlargement of body parts, causing pain, serious disability and social stigma.
Doharey, Pawan Kumar, Omer, Ankur, Saxena, Jitendra Kumar, Singh, Poonam, Verma, Pravesh, Yadav, Sunita   +5 more
core   +1 more source

Snowy cotyledon 2: the identification of a zinc finger domain protein essential for chloroplast development in cotyledons but not in true leaves [PDF]

, 2018
In cotyledons of etiolated seedlings light-dependent transformation of etioplasts to chloroplasts marks the transition from heterotrophic to autotrophic growth.
Albrecht, Verónica, Apel, Klaus, Ingenfeld, Anke   +2 more
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The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication

Journal of Virology
Feline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez, Jaury Gómez de la Madrid, Erick Ignacio Monge-Celestino, Carolina Pérez-Ibáñez, Randy Seir Llanas Vázquez, Sharon Itzel Sosa Mondragon, Carlos Emilio Miguel-Rodríguez, Ana Lorena Gutiérrez-Escolano   +7 more
doaj   +1 more source

Atypical thioredoxin Patrx2 enhances alginate production in mucoid Pseudomonas aeruginosa

Redox Biology
Pseudomonas aeruginosa, an opportunistic human pathogen, is known for its ability to respond and adapt to its environment, employing intricate adaptation mechanisms that can lead to the formation of complex biofilms.
Marie M. Grandjean, James N. Sturgis, Edwige B. Garcin, Moly Ba, Olivier Bornet, Christophe Bordi, Latifa Elantak, Corinne Sebban-Kreuzer   +7 more
doaj   +1 more source

Expression of protein disulfide isomerase A3Q481K variant associated with amyotrophic lateral sclerosis triggers disease features in mice

Neurobiology of Disease
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated
Martin Sepulveda, Francisca Martínez Traub, Patricia Ojeda, Viviana Perez, Jorge Ojeda, Jessica Mella, Rodrigo Diaz, Pablo Rozas, Matías Mansilla-Jaramillo, Amparo Zuleta, Guillermo Diaz, Bredford Kerr, Ute Woehlbier, Juan Pablo Henríquez, Danilo B. Medinas, Claudio Hetz   +15 more
doaj   +1 more source

Selenium‐Centered Cascade Exchangers and Conformational Control Unlock Unique Patterns of Thiol‐Mediated Cellular Uptake

ChemistryEurope
Dynamic‐covalent electrophiles called cascade exchangers (CAXs) can reversibly engage cell‐surface thiols. Conjugates between CAXs and molecular or even protein‐sized cargos can deliver these cargos into cells by thiol‐mediated uptake (TMU); free CAXs ...
Filipe Coelho, Lukas Zeisel, Prof. Oliver Thorn‐Seshold, Prof. Stefan Matile   +3 more
doaj   +1 more source

\u3cem\u3eDrosophila\u3c/em\u3e Vitelline Membrane Assembly: A Critical Role for an Evolutionarily Conserved Cysteine in the “VM domain” of sV23 [PDF]

, 2010
The vitelline membrane (VM), the oocyte proximal layer of the Drosophila eggshell, contains four major proteins (VMPs) that possess a highly conserved “VM domain” which includes three precisely spaced, evolutionarily conserved, cysteines (CX7CX8C ...
Beauchamp, J. M., Manogaran, Anita L., Waring, Gail L., Wu, T.   +3 more
core   +1 more source

Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole [PDF]

, 2017
Objectives The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole nitazoxanide [2-acetolyloxy-N-(5-nitro 2-thiazolyl) benzamide] as the parent compound of thiazolides, a novel class of anti-infective ...
Hemphill, Andrew, Müller, Joachim, Müller, Norbert, Sterk, Maaike   +3 more
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