Results 51 to 60 of about 7,315 (215)

High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility [PDF]

, 2013
ERp27 (endoplasmic reticulum protein 27.7 kDa) is a homologue of PDI (protein disulfide-isomerase) localized to the endoplasmic reticulum. ERp27 is predicted to consist of two thioredoxinfold domains homologous with the non-catalytic b and b domains of ...
A. Katrine Wallis, Alanen, Barak, Barbato, Brünger, Byrne, Cornilescu, Delaglio, Denisov, Ellgaard, Freedman, Guddat, Holm, Jacobs, Jansen, Jimenez-Roldan, Kemmink, Klappa, Kober, Koradi, Kozlov, Kozlov, Kozlov, Lappi, Laskowski, Laskowski, Li, Lipari, Lipari, Mark J. Howard, Michelle L. Rowe, Nader T. Amin, Neuhaus, Nguyen, Palmer, Piotto, Richard A. Williamson, Rieping, Robert B. Freedman, Rowe, States, Stephen A. Wells, Suhre, Tian, Wallis, Wang, Wang, Waters, Wells, Wells, Williamson, Wim, Wishart   +52 more
core   +4 more sources

The cuticle [PDF]

, 2007
The nematode cuticle is an extremely flexible and resilient exoskeleton that permits locomotion via attachment to muscle, confers environmental protection and allows growth by molting.
Johnstone, I. J., Page, A. P.
core   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Importance of disulphide bonds for vaccinia virus L1R protein function

Virology Journal, 2005
L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus is ...
Hruby Dennis E, Byrd Chelsea M, Blouch Robert E   +2 more
doaj   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

Molecular Metabolism, 2021
Objective: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding.
Nirav Florian Chhabra, Anna–Lena Amend, Aimée Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K.H. Przemeck, Martin Hrabě de Angelis   +12 more
doaj   +1 more source

Structural and functional characterization of the oxidoreductase a-DsbA1 from wolbachia pipientis

, 2009
The α-proteobacterium Wolbachia pipientis is a highly successful intracellular endosymbiont of invertebrates that manipulates its host\u27s reproductive biology to facilitate its own maternal transmission. The fastidious nature of Wolbachia and the
Frei, Patrick, Glockshuber, Rudi, Heras, Begoña, Iturbe-Ormaetxe, Iñaki, Jarrott, Russell, Kurz, Mareike, Martin, Jennifer L., O’Neill, Scott L., Shouldice, Stephen R., Wouters, Merridee A.   +9 more
core   +1 more source

Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]

, 2006
Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy, Arolas, Arolas, Arolas, Arolas, Baneyx, Bardwell, Cemazar, Cemazar, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chatrenet, Creighton, Creighton, Creighton, Creighton, Creighton, Daggett, Daly, Darby, Dobson, Ellgaard, Francesc X. Aviles, Fuller, Gehrmann, Goldberg, Goldenberg, Heitz, Hogg, Houry, Joan L. Arolas, Jui-Yoa Chang, Klein-Seetharaman, Kortemme, Kuhlman, Laity, Li, Lu, Matagne, Narayan, Narayan, Narayan, Narayan, Onuchic, Permyakov, Ross, Ruoppolo, Ruoppolo, Salamanca, Salvador Ventura, Scheraga, Shimotakahara, Shin, van den Berg, van den Berg, van Mierlo, van Mierlo, Venhudova, Wedemeyer, Weissman, Welker, Welker, Wu, Yang, Zavodszky   +73 more
core   +2 more sources

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin

Virology Journal, 2020
Background Hemagglutinin (HA), as the surface immunogenic protein, is the most important component of influenza viruses. Previous studies showed that the stability of HA was significant for HA’s immunogenicity, and many efforts have been made to ...
Jialing Wu, Yang Wang, Ying Wei, Zhichao Xu, Xin Tan, Zhihui Wu, Jing Zheng, George Dacai Liu, Yongchang Cao, Chunyi Xue   +9 more
doaj   +1 more source