Results 1 to 10 of about 63,783 (230)
Protein disulfide isomerase in cardiovascular disease [PDF]
Experimental and Molecular Medicine, 2020 Exploring enzymes’ influence on cardiovascular disease Efforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases.
Bei Xiong +3 more
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Roles of Protein Disulfide Isomerase in Breast Cancer. [PDF]
Cancers (Basel), 2022 Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has a poor prognosis and higher recurrence rate due to ineffective therapy.
Yang S +8 more
europepmc +5 more sources
Frontiers in Immunology, 2022 BackgroundProtein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide isomerase (PDI) family that participates in protein folding through its protein disulfide isomerase function.
Zewei Tu +18 more
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Functions and mechanisms of protein disulfide isomerase family in cancer emergence. [PDF]
Cell Biosci, 2022 The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome.
Rahman NSA +5 more
europepmc +2 more sources
Protein Disulfide Isomerase and Host-Pathogen Interaction [PDF]
The Scientific World Journal, 2011 Reactive oxygen species (ROS) production by immunological cells is known to cause damage to pathogens. Increasing evidence accumulated in the last decade has shown, however, that ROS (and redox signals) functionally regulate different cellular pathways ...
Beatriz S. Stolf +7 more
doaj +3 more sources
Compact conformations of human protein disulfide isomerase. [PDF]
PLoS ONE, 2014 Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum.
Shang Yang +8 more
doaj +4 more sources
The human protein disulfide isomerase gene family [PDF]
Human Genomics, 2012 Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of proteins known ...
Galligan James J, Petersen Dennis R
doaj +3 more sources
Inhibition of Protein Disulfide Isomerase in Thrombosis. [PDF]
Basic & Clinical Pharmacology & Toxicology, 2016 This MiniReview addresses our current understanding of the mechanisms by which protein disulfide isomerase (PDI) mediates thrombus formation and discusses the potential of blocking thrombosis by targeting PDI.
Roelof H. Bekendam, R. Flaumenhaft
semanticscholar +4 more sources
Mechanistic insights on the reduction of glutathione disulfide by protein disulfide isomerase [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Protein disulfide isomerase (PDI) is a ubiquitous enzyme involved in disulfide bond formation during protein folding. It has been related to neurological diseases (Parkinson or Alzheimer’s) because of unfolded protein response phenomena.
Rui P. P. Neves, P. Fernandes, M. Ramos
semanticscholar +4 more sources
Emerging roles of protein disulfide isomerase in cancer
BMB Reports, 2017 The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins ...
Eun-Yup Lee, Do Hee Lee
semanticscholar +5 more sources