Results 81 to 90 of about 43,163 (273)

Prompting Fab Yeast Surface Display Efficiency by ER Retention and Molecular Chaperon Co-expression. [PDF]

, 2019
For antibody discovery and engineering, yeast surface display (YSD) of antigen-binding fragments (Fabs) and coupled fluorescence activated cell sorting (FACS) provide intact paratopic conformations and quantitative analysis at the monoclonal level, and ...
Ge, Xin, Iverson, Brent L, Lee, Ki Baek, Li, Junhong, Mei, Meng, Wang, Shengchen, Yi, Li, Zhang, Guimin   +7 more
core  

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis [PDF]

, 2008
Wolbachia pipientis are obligate endosymbionts that infect a wide range of insect and other arthropod species. They act as reproductive parasites by manipulating the host reproduction machinery to enhance their own transmission. This unusual phenotype is
Alun Jones, Bardwell, Begoña Heras, Collet, Debarbieux, Edeling, Ellermeier, Ellman, Floate, Gautier Robin, Gordon J. King, Goulding, Gruber, Heras, Hillson, Holmgren, Iñaki Iturbe-Ormaetxe, Jennifer L. Martin, Jeyaprakash, Kadokura, Kelley, Mareike Kurz, Martin, Martin, McCarthy, Messens, Nakamoto, Nathan Cowieson, O’Neill, O’Neill, Patrick Frei, Raina, Riegler, Rietsch, Rudi Glockshuber, Russell Jarrott, Sambrook, Scott L. O’Neill, Studier, Taylor, Taylor, Werren, Wu, Yu   +43 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.

PLoS ONE, 2013
Protein disulfide isomerases comprise a large family of enzymes responsible for catalyzing the proper oxidation and folding of newly synthesized proteins in the endoplasmic reticulum (ER). Protein disulfide isomerase-related (PDIR) protein (also known as
Roohi Vinaik, Guennadi Kozlov, Kalle Gehring   +2 more
doaj   +1 more source

Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells [PDF]

, 2014
Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC).
Chiappetta, G, Di Maro, G, Jarzab, B, Masullo, M, Monaco, M, Oczko-Wojciechowska, M, Orlandella, FM, Salerno, P, Salvatore, G, Santoro, M, Thomas, G, Unger, K   +11 more
core   +1 more source

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, EarlyView.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells

Redox Biology, 2017
Extracellular pools of intracellular molecular chaperones are increasingly evident. The peri/epicellular(pec) pool of the endoplasmic reticulum redox chaperone protein disulfide isomerase-A1(PDI) is involved in thrombosis and vascular remodeling, while ...
Thaís L.S. Araujo, Carolina G. Fernandes, Francisco R.M. Laurindo   +2 more
doaj   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes [PDF]

, 2012
Recently, missense mutations upstream of preproinsulin’s signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY).
Arvan, Peter, Barbetti, Fabrizio, Guo, Huan, Haataja, Leena, Lara-Lemus, Roberto, Larkin, Dennis, Liu, Ming, Shan, Shu-ou, Wright, Jordan   +8 more
core   +1 more source