Results 261 to 270 of about 4,544,497 (292)

Evidence of Anti-amyloid Characteristics of Plumbagin via Inhibition of Protein Aggregation and Disassembly of Protein Fibrils

Biomacromolecules, 2021
The biological consequences associated with the conversion of soluble proteins into insoluble toxic amyloids are not only limited to the onset of neurodegenerative diseases but also to the potential health risks associated with supplements of protein therapeutic agents as well.
Bibin G. Anand, Kailash P. Prajapati, Sampreeta Purohit, Masihuzzaman Ansari, Ayoushna Panigrahi, Bharti Kaushik, Rajendra Kumar Behera, Karunakar Kar   +7 more
openaire   +2 more sources

Off-pathway aggregation can inhibit fibrillation at high protein concentrations

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
Ribosomal protein S6 fibrillates readily at slightly elevated temperatures and acidic pH. We find that S6 fibrillation is retarded rather than favored when the protein concentration is increased above a threshold concentration of around 3.5mg/mL. We name this threshold concentration C(FR), the concentration at which fibrillation is retarded.
Deva, Taru, Lorenzen, Nikolai, Vad, Brian S, Petersen, Steen V, Thørgersen, Ida, Enghild, Jan J; id_orcid 0000-0001-9292-9172, Kristensen, Torsten, Otzen, Daniel   +7 more
openaire   +3 more sources

Copper(II) Inhibits in Vitro Conversion of Prion Protein into Amyloid Fibrils

Biochemistry, 2005
In recent studies, the amyloid fibrils produced in vitro from recombinant prion protein encompassing residues 89-230 (rPrP 89-230) were shown to produce transmissible form of prion disease in transgenic mice (Legname et al., (2004) Science 305, 673-676).
Olga V, Bocharova, Leonid, Breydo, Vadim V, Salnikov, Ilia V, Baskakov   +3 more
openaire   +2 more sources

Myricetin inhibits amyloid fibril formation of globular proteins by stabilizing the native structures

Colloids and Surfaces B: Biointerfaces, 2020
Myricetin has been identified as a naturally occurring flavonoid class of polyphenolic compound which shows multiple medical benefits including antidiabetic, anticancerous and antioxidant properties. Here, we report the protective effect of myricetin against in vitro amyloid fibril formation of selected globular proteins.
Kailash P. Prajapati, Akhilesh P. Singh, Kriti Dubey, Masihuzzaman Ansari, Mayur Temgire, Bibin G. Anand, Karunakar Kar   +6 more
openaire   +2 more sources

Aloe Vera Inhibits Protein Fibrillation: Mechanistic Biophysical Evaluation

Langmuir
The aggregation of proteins and the formation of amyloid fibrils as a result of protein misfolding are thought to be strongly linked to neurodegenerative disorders, including those driven by infectious prions, Alzheimer's disease, and Parkinson's disease, to name only a few.
Anu Jain, Nand Kishore
openaire   +2 more sources

Entactin-induced inhibition of human amyloid β-protein fibril formation in vitro

Neuroscience Letters, 2001
Amyloid beta-protein (Abeta) fibril in senile plaques may possibly be related to the pathogenesis of Alzheimer's disease (AD). Basement membrane (BM) components are localized to the plaques. Entactin binds the plaque associated BM components. We investigated the potential of entactin to prevent Abeta fibril formation.
Y, Kiuchi, Y, Isobe, K, Fukushima
openaire   +2 more sources

Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity

The Journal of Physical Chemistry B, 2016
Accumulation and aggregation of amyloid β-protein (Aβ) play an important role in the pathogenesis of Alzheimer's disease. There has been increased interest in finding new anti-amyloidogenic compounds to inhibit Aβ aggregation. Herein, thioflavin T fluorescent assay and transmission electron microscopy results showed that hematoxylin, a natural organic ...
Yilong, Tu, Shuai, Ma, Fufeng, Liu, Yan, Sun, Xiaoyan, Dong   +4 more
openaire   +2 more sources

Inhibition of amyloid-β protein fibrillization upon interaction with polyoxometalates nanoclusters

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2011
In this paper, two representative polyoxometalates (POMs), the wheel-shaped Preyssler anion INaP(5)W(30)O(110)](14-) (P5W30) and the Keggin-type anion [H(2)W(12)O(40)](6-) (H2W12) are shown to interact with A beta 1-40 and to inhibit its fibrillization.
Yawen Zhou, Li Zheng, Fu Han, Guangjin Zhang, Ying Ma, Jiannian Yao, Bineta Keita, Pedro de Oliveira, Louis Nadjo   +8 more
openaire   +1 more source

Inhibition of Aβ fibril formation and Aβ-induced cytotoxicity by senile plaque-associated proteins

Neuroscience Letters, 2000
A beta neurotoxicity is generally believed to require A beta fibril formation. The prevention of A beta fibril formation thus seems to be a promising strategy for the treatment of AD. Recent studies have shown senile plaque-associated proteins such as laminin to have an inhibitory effect on both A beta40 and A beta42 fibril formation in vitro.
A, Monji, I, Yoshida, K, Tashiro, Y, Hayashi, K, Matsuda, N, Tashiro   +5 more
openaire   +2 more sources

Inhibition of β-Amyloid Fibrillization by Directed Evolution of a β-Sheet Presenting Miniature Protein

Journal of the American Chemical Society, 2006
We describe the directed evolution of a miniature beta-sheet protein for targeting beta-amyloid oligomers implicated in Alzheimer's disease. Circular dichroism spectroscopy, thermal denaturation experiments, and immunoglobulin binding assays established that our beta-amyloid-targeted miniature protein, TJ10, presents a well-folded thermostable beta ...
Thaddeus J, Smith, Cliff I, Stains, Scott C, Meyer, Indraneel, Ghosh   +3 more
openaire   +2 more sources