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Understanding the mechanism of formation and inhibition of protein fibrils for treatment and prevention of neurodegenerative disease

Neurodegenerative disorders such as Alzheimer’s disease (AD) are characterised by permanent & progressive impairment to cognitive function. Amyloid-beta (Aβ) peptide which is formed by cleavage of the amyloid precursor protein (APP), undergoes significant morphological changes that result in aggregation and the formation of β-sheet fibril plaque ...
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Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase

Circulation, 2020
Javid J. Moslehi   +2 more
exaly  

Protein fibril–mediated inhibition of lotus seed starch retrogradation

Carbohydrate Polymers
Huifang Liu   +5 more
openaire   +1 more source

Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation

Chinese Journal of Polymer Science
Hui Wang   +3 more
openaire   +1 more source

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