3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
Advanced Functional Materials, EarlyView.A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]
, 1975 An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core +2 more sources
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Advanced Functional Materials, EarlyView.Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
Molecular Basis for Environment Sensing by a Nucleoid-Structuring Bacterial Protein Filament. [PDF]
J Phys Chem Lett, 2021 Zhao X +4 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz +7 more
wiley +1 more source
Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains. [PDF]
, 2012 Formins are a conserved family of proteins known to enhance actin polymerization. Most formins are regulated by an intramolecular interaction. The Drosophila formin, Cappuccino (Capu), was believed to be an exception.
Bor, Batbileg +3 more
core +2 more sources
3D Bioinspired Hair‐Based Solar Evaporator for Efficient Water Harvesting
Advanced Functional Materials, EarlyView.A bio‐derived solar evaporator inspired by blackbody radiation is developed using human hair waste. The vertically aligned hair structure enables broadband light absorption, efficient thermal localization, and rapid water transport, achieving high evaporation rates and stable desalination performance.
Yi Liu +10 more
wiley +1 more source
Insights into the dynamic trajectories of protein filament division revealed by numerical investigation into the mathematical model of pure fragmentation. [PDF]
PLoS Comput Biol, 2021 Tournus M, Escobedo M, Xue WF, Doumic M.
europepmc +1 more source
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
European Journal of Cell BiologyCardiac muscle α-actin is a key protein of the thin filament in the muscle sarcomere that, together with myosin thick filaments, produce force and contraction important for normal heart function.
Hsiang-Ling Huang +5 more
doaj +1 more source