Results 11 to 20 of about 250,840 (309)

Collaborative protein filaments

The EMBO Journal, 2015
AbstractIt is now well established that prokaryotic cells assemble diverse proteins into dynamic cytoskeletal filaments that perform essential cellular functions. Although most of the filaments assemble on their own to form higher order structures, growing evidence suggests that there are a number of prokaryotic proteins that polymerise only in the ...
Ghosal, D, Loewe, J
openaire   +3 more sources

The Biological Role of Nestin(+)-Cells in Physiological and Pathological Cardiovascular Remodeling

Frontiers in Cell and Developmental Biology, 2018
The intermediate filament protein nestin was identified in diverse populations of cells implicated in cardiovascular remodeling. Cardiac resident neural progenitor/stem cells constitutively express nestin and following an ischemic insult migrate to the ...
Angelino Calderone, Angelino Calderone
doaj   +1 more source

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

Nature Communications, 2021
The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectively ...
Johanna Funk, Felipe Merino, Matthias Schaks, Klemens Rottner, Stefan Raunser, Peter Bieling   +5 more
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The N-Terminal Part of the 1A Domain of Desmin Is a Hot Spot Region for Putative Pathogenic DES Mutations Affecting Filament Assembly

Cells, 2022
Desmin is the major intermediate filament protein of all three muscle cell types, and connects different cell organelles and multi-protein complexes such as the cardiac desmosomes. Several pathogenic mutations in the DES gene cause different skeletal and
Andreas Brodehl, Stephanie Holler, Jan Gummert, Hendrik Milting   +3 more
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Structure of native glycolipoprotein filaments in honeybee royal jelly

Nature Communications, 2020
Female honeybee larvae develop into queens when they are fed exclusively with royal jelly (RJ) and major royal jelly protein 1 (MRJP1) is the main protein component of RJ. Here, the authors present the 3.5 Å cryo-EM structure of native RJ filament, where
Simone Mattei, Arvid Ban, Armin Picenoni, Marc Leibundgut, Rudi Glockshuber, Daniel Boehringer   +5 more
doaj   +1 more source

Intermediate Filament Protein Partnership in Astrocytes [PDF]

Journal of Biological Chemistry, 1999
Intermediate filaments are general constituents of the cytoskeleton. The function of these structures and the requirement for different types of intermediate filament proteins by individual cells are only partly understood. Here we have addressed the role of specific intermediate filament protein partnerships in the formation of intermediate filaments ...
C, Eliasson, C, Sahlgren, C H, Berthold, J, Stakeberg, J E, Celis, C, Betsholtz, J E, Eriksson, M, Pekny   +7 more
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Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA. [PDF]

, 2012
Escherichia coli RecA is the defining member of a ubiquitous class of DNA strand-exchange proteins that are essential for homologous recombination, a pathway that maintains genomic integrity by repairing broken DNA.
Bell, Jason C, Dombrowski, Christopher C, Kowalczykowski, Stephen C, Plank, Jody L   +3 more
core   +2 more sources

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi, Bergerat, Bishop, Brown, Brunger, Bugreev, Byung-Ha Oh, Case, Chan, Chen, Chi, Cho, Christopher P. Toseland, Cloud, de Massy, De Vlaminck, de Vries, Emsley, Enomoto, Ferrari, Garcia, Haruta, Hayase, Ho-Chul Shin, Holm, Hyun-Ah Kang, Hyun-Min Kim, Keeney, Keeney, Kokabu, Kuwabara, Lange, Leu, Lu, Lu, Lu, Matteo Dal Peraro, Moktan, Morrison, Neale, Okorokov, Otwinowski, Pettersen, Petukhova, Petukhova, Pezza, Pezza, Phillips, Ploquin, Qiao, Rabitsch, Roeder, Rothenberg, Say, Schwacha, Sheridan, Sheridan, Soding, Stephan Gruber, Terwilliger, Tsai, Tsubouchi, Tsubouchi, Uanschou, van der Heijden, Wright, Zhao   +66 more
core   +3 more sources

Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases

Nature Communications, 2023
Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51-ssDNA filament. How the Rad51 filament is efficiently established and sustained remains partially understood. Here, we find that
Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen   +14 more
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The DinI Protein Stabilizes RecA Protein Filaments [PDF]

Journal of Biological Chemistry, 2004
When DinI is present at concentrations that are stoichiometric with those of RecA or somewhat greater, DinI has a substantial stabilizing effect on RecA filaments bound to DNA. Exchange of RecA between free and bound forms was almost entirely suppressed, and highly stable filaments were documented with several different experimental methods.
Shelley L, Lusetti, Oleg N, Voloshin, Ross B, Inman, R Daniel, Camerini-Otero, Michael M, Cox   +4 more
openaire   +2 more sources