Results 1 to 10 of about 6,771,465 (361)

Protein folds vs. protein folding: Differing questions, different challenges

Proceedings of the National Academy of Sciences, 2022
No ...
Shi-Jie Chen, Mubashir Hassan, Robert L. Jernigan, Kejue Jia, Daisuke Kihara, Andrzej Kloczkowski, Sergei Kotelnikov, Dima Kozakov, Jie Liang, Adam Liwo, Silvina Matysiak, Jarek Meller, Cristian Micheletti, Julie C. Mitchell, Sayantan Mondal, Ruth Nussinov, Kei-ichi Okazaki, Dzmitry Padhorny, Jeffrey Skolnick, Tobin R. Sosnick, George Stan, Ilya Vakser, Xiaoqin Zou, George D. Rose   +23 more
openaire   +4 more sources

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1–4, the structures of around 100,000 unique proteins have been determined5, but this ...
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly   +2 more sources

The Protein Folding Problem [PDF]

Annual Review of Biophysics, 2008
The “protein folding problem” consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years.
Dill, K., Ozkan, S., Shell, M., Weikl, T.   +3 more
openaire   +4 more sources

Cotranslational protein folding through non-native structural intermediates. [PDF]

Sci Adv
Wang S, Bitran A, Samatova E, Shakhnovich EI, Rodnina MV.   +4 more
europepmc   +3 more sources

Comprehensive Folding Variations for Protein Folding [PDF]

Proteins: Structure, Function, and Bioinformatics, 2022
The revelation of protein folding is a challenging subject in both discovery and description. Except acquirement of accurate 3D structure for protein stable state, another big hurdle is how to discover structural flexibility for protein innate character.
Jiaan Yang, Wen Xiang Cheng, Xiao Fei Zhao, Gang Wu, Shi Tong Sheng, Qiyue Hu, Hu Ge, Qianshan Qin, Xinshen Jin, Lianshan Zhang, Peng Zhang   +10 more
openaire   +2 more sources

Validation of the "Stoichiometric Hydration Ice-Bridge Model" Provides Method To Predict Protein Folding Energetics. [PDF]

J Phys Chem B
Fullerton GD, Rahal A.
europepmc   +2 more sources

ColabFold: making protein folding accessible to all

Nature Methods, 2022
ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold.
M. Mirdita, S. Ovchinnikov, Martin Steinegger   +2 more
semanticscholar   +1 more source

Mega-scale experimental analysis of protein folding stability in biology and design

Nature, 2023
Large-scale assays using cDNA display proteolysis are used to measure the folding stabilities of protein domains, providing a method to quantify the effects of mutations on protein folding, with applications in protein design.
Kotaro Tsuboyama, J. Dauparas, Jonathan Chen, É. Laine, Yasser Mohseni Behbahani, Jonathan J Weinstein, N. Mangan, S. Ovchinnikov, G. Rocklin   +8 more
semanticscholar   +1 more source

Protein folding [PDF]

Journal of Cellular and Molecular Medicine, 2003
AbstractThe problem of protein folding is that how proteins acquire their native unique three‐dimensional structure in the physiological milieu. To solve the problem, the following key questions should be answered: do proteins fold co‐ or post‐translationally, i.e.
Maurice Eftink, Susan Pedigo
openaire   +3 more sources

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

BMC Biology, 2021
Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway   +8 more
doaj   +1 more source