Results 241 to 250 of about 11,990,533 (304)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Genetically encoded green-light-responsive photocaged lysine for sequential control of protein function. [PDF]

Chem Sci
Li M, Lu M, Wang L, Zhang Y, Yan L, Wang S, Peng T.   +6 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predicting Protein Function in the AI and Big Data Era. [PDF]

Biochemistry
Percudani R, De Rito C.
europepmc   +1 more source

Correction: ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC

Cell Death and Disease
Tongjia Zhang, Lizhen Qiu, Jiashun Cao, Qiu Li, Lifan Zhang, Guoshun An, Juhua Ni, Hongti Jia, Shuyan Li, Kailong Li   +9 more
doaj   +1 more source

The membrane properties determine protein function: A new aspect of allosteric modulation. [PDF]

Biophys J
Huster D.
europepmc   +1 more source

Dynamic Allostery: Evolution's Double-Edged Sword in Protein Function and Disease. [PDF]

J Mol Biol
Campitelli P, Kazan IC, Hamilton S, Ozkan SB.   +3 more
europepmc   +1 more source

GOBeacon: An ensemble model for protein function prediction enhanced by contrastive learning. [PDF]

Protein Sci
Lin W, Miller D, Gu Z, Orengo C.
europepmc   +1 more source

GOAnnotator: accurate protein function annotation using automatically retrieved literature. [PDF]

Bioinformatics
Yan H, Liu H, Wang S, Zhu S.
europepmc   +1 more source

SuperEdgeGO: Edge-supervised graph representation learning for enhanced protein function prediction. [PDF]

PLoS Comput Biol
Zhang S, Li Y, Ma W, Cai Q, Qin J, Bi X, Jiang H, Huang X, Wei Z.   +8 more
europepmc   +1 more source