Results 261 to 270 of about 11,494,730 (307)

A Function for the Prion Protein?

2003
Protein function is often observed directly following protein isolation, or is deduced by loss of function following gene knockout or by analogy with proteins of known function and similar amino acid sequence. None of these is true in the case of prion proteins because aside from the association with the pathogenesis of the spongiform encaphalopathies,
D R, Brown, I M, Jones
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Protein Function Prediction

2017
Protein function is a concept that can have different interpretations in different biological contexts, and the number and diversity of novel proteins identified by large-scale "omics" technologies poses increasingly new challenges. In this review we explore current strategies used to predict protein function focused on high-throughput sequence ...
Leonardo Magalhães, Cruz, Sheyla, Trefflich, Vinícius Almir, Weiss, Mauro Antônio Alves, Castro   +3 more
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The functions of Myc proteins

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1992
The functions of Myc proteins have remained a mystery for a number of years. Recent data have now provided us with a clear working hypothesis of how myc may act. What appears to be still missing is a link between the biochemical properties of this oncoprotein and its observed biological effects. Further research will be necessary to fill this void.
A, Meichle, A, Philipp, M, Eilers
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Globularity and Protein Function

Journal of Biomolecular Structure and Dynamics, 2000
Abstract The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside.
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FUNCTIONAL SIGNIFICANCE OF FLEXIBILITY IN PROTEINS

Acta Crystallographica Section A Foundations of Crystallography, 1982
Abstract
R, Huber, W S, Bennett
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Semantically predicting protein functions based on protein functional connectivity

Computational Biology and Chemistry, 2013
The current availability of public protein-protein interaction (PPI) databases which are usually modelled as PPI networks has led to the rapid development of protein function prediction approaches. The existing network-based prediction approaches mainly focus on the topological similarities between immediately interacting proteins, neglecting the ...
Wei Zhu 0014, Jingyu Hou 0001, Yi-Ping Phoebe Chen   +2 more
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Protein Hydration and Function

1991
Publisher Summary Hydration can be considered a process of adding water incrementally to dry protein, until a level of hydration is reached beyond which further addition of water produces no change and only dilutes the protein. The hydration process has several stages and an end point, reflected similarly in different types of measurements.
J A, Rupley, G, Careri
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FUNCTION PREDICTION OF UNCHARACTERIZED PROTEINS

Journal of Bioinformatics and Computational Biology, 2007
Function prediction of uncharacterized protein sequences generated by genome projects has emerged as an important focus for computational biology. We have categorized several approaches beyond traditional sequence similarity that utilize the overwhelmingly large amounts of available data for computational function prediction, including structure ...
Troy Hawkins, Daisuke Kihara
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Membrane Protein Function

2013
Legacy description not ...
Alan Goddard, Joanne Oates, Anthony Watts   +2 more
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DNA-Functionalized, Bivalent Proteins*

Journal of the American Chemical Society, 2018
Bivalent DNA conjugates of β-galactosidase (βGal), having pairs of oligonucleotides positioned closely on opposing faces of the protein, have been synthesized and characterized. These structures, due to their directional bonding characteristics, allow for the programmable access of one-dimensional protein materials.
Janet R. McMillan, Chad A. Mirkin
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