Results 261 to 270 of about 11,990,533 (304)
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Protein Hydration and Function
1991Publisher Summary Hydration can be considered a process of adding water incrementally to dry protein, until a level of hydration is reached beyond which further addition of water produces no change and only dilutes the protein. The hydration process has several stages and an end point, reflected similarly in different types of measurements.
J A, Rupley, G, Careri
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Prediction of protein functions based on function–function correlation relations
Computers in Biology and Medicine, 2010A protein function pair approach, based on protein-protein interaction (PPI) data, is proposed to predict protein functions. Randomization tests are performed on the PPI dataset, which resulted in a protein function correlation scoring value which is used to rank the relative importance of a function pair.
Ka-Lok Ng +2 more
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FUNCTION PREDICTION OF UNCHARACTERIZED PROTEINS
Journal of Bioinformatics and Computational Biology, 2007Function prediction of uncharacterized protein sequences generated by genome projects has emerged as an important focus for computational biology. We have categorized several approaches beyond traditional sequence similarity that utilize the overwhelmingly large amounts of available data for computational function prediction, including structure ...
Troy Hawkins, Daisuke Kihara
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DNA-Functionalized, Bivalent Proteins*
Journal of the American Chemical Society, 2018Bivalent DNA conjugates of β-galactosidase (βGal), having pairs of oligonucleotides positioned closely on opposing faces of the protein, have been synthesized and characterized. These structures, due to their directional bonding characteristics, allow for the programmable access of one-dimensional protein materials.
Janet R. McMillan, Chad A. Mirkin
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Functions of the retinoblastoma protein
BioEssays, 1999The retinoblastoma protein (pRB) can both positively and negatively regulate transcription. The former correlates with its ability to promote differentiation and the latter with its ability to regulate entry into S-phase. pRB negatively regulates transcription by forming complexes with members of the E2F transcription factor family.
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Protein Ubiquitylation and Synaptic Function
Annals of the New York Academy of Sciences, 2003Abstract: Conjugation of ubiquitin to proteins is a well‐established signal to regulate an ever expanding range of cellular processes. Here, we discuss recent findings that deeply link ubiquitin signaling to synaptic activity.
O. Cremona, COLLESI, CHIARA, E. Raiteri
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Protein-Functionalized Polymer Brushes
Biomacromolecules, 2005A new strategy for the preparation of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymerization (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subsequent O(6)-benzylguanine (BG) functionalization.
Tugulu, Stefano +7 more
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Prediction of Protein Functions
2011The recent explosion in the number and diversity of novel proteins identified by the large-scale "omics" technologies poses new and important questions to the blossoming field of systems biology--what are all these proteins, how did they come about, and most importantly, what do they do? From a comparatively small number of protein structural domains a
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Proteins: Dynamics and Function
1988The focus in my paper changes from the genes to gene products, which are proteins. I will describe some of the results of theoretical methods that are used to understand the functioning of these gene products. Since there is no plan for a “human protein consortium,” I will restrict myself to describing what has been going on in this area.
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