Results 261 to 270 of about 521,366 (318)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6b

, 2004
Alain Expert-Bezançon, Alain Sureau, Patrice Durosay, Roland Salesse, H. T. Groeneveld, Jean‐Pierre LeCaer, Joëlle Marie   +6 more
openalex   +1 more source

G-protein Coupled Receptor Kinase-Interacting Protein 1(GIT1) Regulates Endothelial Cell Function: Role in PodosomeFormation, Extracellular Matrix Degradation andMigration

, 2009
Jing Wang
openalex   +1 more source

Reversible modifications of chloroplast proteins and assessment of their functions

, 2012
Björn Ingelsson
openalex   +1 more source

Structure-function studies of the staphylococcal complement inhibitor protein family

, 2012
Brandon L. Garcia
openalex   +1 more source

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Prediction of protein functions based on function–function correlation relations

Computers in Biology and Medicine, 2010
A protein function pair approach, based on protein-protein interaction (PPI) data, is proposed to predict protein functions. Randomization tests are performed on the PPI dataset, which resulted in a protein function correlation scoring value which is used to rank the relative importance of a function pair.
Ka-Lok Ng, Jin-Shuei Ciou, Chien-Hung Huang   +2 more
exaly   +3 more sources

Functions of S100 Proteins

Current Molecular Medicine, 2012
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
DONATO, Rosario Francesco, Cannon B. R., SORCI, Guglielmo, RIUZZI, Francesca, Hsu K., Weber D. J., Geczy C. L.   +6 more
openaire   +3 more sources

Response functions of proteins

Biophysical Chemistry, 2000
The thermodynamics of protein folding can be studied by a variety of different techniques such as differential scanning calorimetry, differential scanning densimetry and sound velocity measurements. These three methods monitor the different response functions heat capacity, expansion coefficient and compressibility that characterise various aspects of ...
J, Rösgen, H J, Hinz
openaire   +2 more sources

Functional protein microarrays

Current Opinion in Chemical Biology, 2002
Microarrays of immobilized functional proteins have the potential to increase dramatically the throughput of proteomic analysis. Micro-immunoassays, in which biological samples are exposed to arrays of immobilized antibodies, can be used for protein expression profiling.
David S, Wilson, Steffen, Nock
openaire   +2 more sources