Results 271 to 280 of about 521,366 (318)

Protein Function in the Crystal

Annual Review of Biophysics and Biomolecular Structure, 1996
Protein crystals contain wide solvent-filled channels that allow for traffic of metabolites and intramolecular motility. Ligand binding, catalysis and allosteric regulation occur in the crystalline environment but intermolecular interactions may hinder function-associated transitions and alter activity with respect to solution. Lattice constraints have,
MOZZARELLI, Andrea, ROSSI, Gian Luigi
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The functions of Myc proteins

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1992
The functions of Myc proteins have remained a mystery for a number of years. Recent data have now provided us with a clear working hypothesis of how myc may act. What appears to be still missing is a link between the biochemical properties of this oncoprotein and its observed biological effects. Further research will be necessary to fill this void.
A, Meichle, A, Philipp, M, Eilers
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Protein Hydration and Function

1991
Publisher Summary Hydration can be considered a process of adding water incrementally to dry protein, until a level of hydration is reached beyond which further addition of water produces no change and only dilutes the protein. The hydration process has several stages and an end point, reflected similarly in different types of measurements.
J A, Rupley, G, Careri
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A Function for the Prion Protein?

2003
Protein function is often observed directly following protein isolation, or is deduced by loss of function following gene knockout or by analogy with proteins of known function and similar amino acid sequence. None of these is true in the case of prion proteins because aside from the association with the pathogenesis of the spongiform encaphalopathies,
D R, Brown, I M, Jones
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Globularity and Protein Function

Journal of Biomolecular Structure and Dynamics, 2000
Abstract The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside.
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FUNCTIONAL SIGNIFICANCE OF FLEXIBILITY IN PROTEINS

Acta Crystallographica Section A Foundations of Crystallography, 1982
Abstract
R, Huber, W S, Bennett
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Semantically predicting protein functions based on protein functional connectivity

Computational Biology and Chemistry, 2013
The current availability of public protein-protein interaction (PPI) databases which are usually modelled as PPI networks has led to the rapid development of protein function prediction approaches. The existing network-based prediction approaches mainly focus on the topological similarities between immediately interacting proteins, neglecting the ...
Wei Zhu 0014, Jingyu Hou 0001, Yi-Ping Phoebe Chen   +2 more
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Membrane Protein Function

2013
Legacy description not ...
Alan Goddard, Joanne Oates, Anthony Watts   +2 more
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Protein Function Prediction

2017
Protein function is a concept that can have different interpretations in different biological contexts, and the number and diversity of novel proteins identified by large-scale "omics" technologies poses increasingly new challenges. In this review we explore current strategies used to predict protein function focused on high-throughput sequence ...
Leonardo Magalhães, Cruz, Sheyla, Trefflich, Vinícius Almir, Weiss, Mauro Antônio Alves, Castro   +3 more
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FUNCTION PREDICTION OF UNCHARACTERIZED PROTEINS

Journal of Bioinformatics and Computational Biology, 2007
Function prediction of uncharacterized protein sequences generated by genome projects has emerged as an important focus for computational biology. We have categorized several approaches beyond traditional sequence similarity that utilize the overwhelmingly large amounts of available data for computational function prediction, including structure ...
Troy Hawkins, Daisuke Kihara
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