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SuperEdgeGO: Edge-supervised graph representation learning for enhanced protein function prediction. [PDF]

open access: yesPLoS Comput Biol
Zhang S   +8 more
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Prediction of protein functions based on function–function correlation relations

Computers in Biology and Medicine, 2010
A protein function pair approach, based on protein-protein interaction (PPI) data, is proposed to predict protein functions. Randomization tests are performed on the PPI dataset, which resulted in a protein function correlation scoring value which is used to rank the relative importance of a function pair.
Ka-Lok Ng   +2 more
exaly   +3 more sources

Protein Function in the Crystal

Annual Review of Biophysics and Biomolecular Structure, 1996
Protein crystals contain wide solvent-filled channels that allow for traffic of metabolites and intramolecular motility. Ligand binding, catalysis and allosteric regulation occur in the crystalline environment but intermolecular interactions may hinder function-associated transitions and alter activity with respect to solution. Lattice constraints have,
MOZZARELLI, Andrea, ROSSI, Gian Luigi
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Functions of S100 Proteins

Current Molecular Medicine, 2012
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
DONATO, Rosario Francesco   +6 more
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Response functions of proteins

Biophysical Chemistry, 2000
The thermodynamics of protein folding can be studied by a variety of different techniques such as differential scanning calorimetry, differential scanning densimetry and sound velocity measurements. These three methods monitor the different response functions heat capacity, expansion coefficient and compressibility that characterise various aspects of ...
J, Rösgen, H J, Hinz
openaire   +2 more sources

Functional protein microarrays

Current Opinion in Chemical Biology, 2002
Microarrays of immobilized functional proteins have the potential to increase dramatically the throughput of proteomic analysis. Micro-immunoassays, in which biological samples are exposed to arrays of immobilized antibodies, can be used for protein expression profiling.
David S, Wilson, Steffen, Nock
openaire   +2 more sources

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