Results 251 to 260 of about 11,990,533 (304)

Protein Function in the Crystal

Annual Review of Biophysics and Biomolecular Structure, 1996
Protein crystals contain wide solvent-filled channels that allow for traffic of metabolites and intramolecular motility. Ligand binding, catalysis and allosteric regulation occur in the crystalline environment but intermolecular interactions may hinder function-associated transitions and alter activity with respect to solution. Lattice constraints have,
MOZZARELLI, Andrea, ROSSI, Gian Luigi
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Functions of S100 Proteins

Current Molecular Medicine, 2012
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
DONATO, Rosario Francesco, Cannon B. R., SORCI, Guglielmo, RIUZZI, Francesca, Hsu K., Weber D. J., Geczy C. L.   +6 more
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Response functions of proteins

Biophysical Chemistry, 2000
The thermodynamics of protein folding can be studied by a variety of different techniques such as differential scanning calorimetry, differential scanning densimetry and sound velocity measurements. These three methods monitor the different response functions heat capacity, expansion coefficient and compressibility that characterise various aspects of ...
J, Rösgen, H J, Hinz
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Functional protein microarrays

Current Opinion in Chemical Biology, 2002
Microarrays of immobilized functional proteins have the potential to increase dramatically the throughput of proteomic analysis. Micro-immunoassays, in which biological samples are exposed to arrays of immobilized antibodies, can be used for protein expression profiling.
David S, Wilson, Steffen, Nock
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A Function for the Prion Protein?

2003
Protein function is often observed directly following protein isolation, or is deduced by loss of function following gene knockout or by analogy with proteins of known function and similar amino acid sequence. None of these is true in the case of prion proteins because aside from the association with the pathogenesis of the spongiform encaphalopathies,
D R, Brown, I M, Jones
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Protein Function Prediction

2017
Protein function is a concept that can have different interpretations in different biological contexts, and the number and diversity of novel proteins identified by large-scale "omics" technologies poses increasingly new challenges. In this review we explore current strategies used to predict protein function focused on high-throughput sequence ...
Leonardo Magalhães, Cruz, Sheyla, Trefflich, Vinícius Almir, Weiss, Mauro Antônio Alves, Castro   +3 more
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The functions of Myc proteins

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1992
The functions of Myc proteins have remained a mystery for a number of years. Recent data have now provided us with a clear working hypothesis of how myc may act. What appears to be still missing is a link between the biochemical properties of this oncoprotein and its observed biological effects. Further research will be necessary to fill this void.
A, Meichle, A, Philipp, M, Eilers
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Globularity and Protein Function

Journal of Biomolecular Structure and Dynamics, 2000
Abstract The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside.
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FUNCTIONAL SIGNIFICANCE OF FLEXIBILITY IN PROTEINS

Acta Crystallographica Section A Foundations of Crystallography, 1982
Abstract
R, Huber, W S, Bennett
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Semantically predicting protein functions based on protein functional connectivity

Computational Biology and Chemistry, 2013
The current availability of public protein-protein interaction (PPI) databases which are usually modelled as PPI networks has led to the rapid development of protein function prediction approaches. The existing network-based prediction approaches mainly focus on the topological similarities between immediately interacting proteins, neglecting the ...
Wei Zhu 0014, Jingyu Hou 0001, Yi-Ping Phoebe Chen   +2 more
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