Results 121 to 130 of about 162,600 (208)

Author Correction: Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways. [PDF]

Nat Commun
Zhong C, Li P, Argade S, Liu L, Chillá A, Liang W, Xin H, Eliceiri B, Choudhury B, Ferrara N.   +9 more
europepmc   +1 more source

Alterations in mitochondrial protein glycosylation in myocardial ischaemia reperfusion injury. [PDF]

Biochem Biophys Rep, 2023
Feng X, Shi Q, Jian Q, Li F, Li Z, Cheng K.   +5 more
europepmc   +1 more source

Protein hydrolysates in cell culture: Toward multi‐omics characterization

Biotechnology Progress, EarlyView.
While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe, Brandon M. Wrage, Angel Varela‐Rohena, Stanislav Sokolenko   +3 more
wiley   +1 more source

Multivariate phase‐dependent optimization of bioprocesses boosts performance and quality—Why timing (of exposure) matters

Biotechnology Progress, EarlyView.
Abstract Applying a single parameter set to describe complex mammalian kinetics often is too simplistic, as it fails to capture sensitive cell‐to‐environment interactions that may be exploited to optimize production performance. To resolve this time dependency, intra‐experimental parameter shifts as part of design of dynamic experiments (DoDE) can be ...
Samuel Kienzle, Lisa Junghans, Anja Wittmann, Stefan Wieschalka, Ralf Takors, Nicole Erika Radde, Beate Presser, Verena Nold   +7 more
wiley   +1 more source

Restoring protein glycosylation with GlycoShape. [PDF]

Nat Methods
Ives CM, Singh O, D'Andrea S, Fogarty CA, Harbison AM, Satheesan A, Tropea B, Fadda E.   +7 more
europepmc   +1 more source

Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications. [PDF]

Oncogene, 2023
Wang Y, Chen H.
europepmc   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Glycoprotein-Notebook: A Pan-Cancer Glycoproteomic Database and Toolkit for Analysis of Protein Glycosylation Changes Associated With Cancer Phenotypes. [PDF]

Mol Cell Proteomics
Zhang H, Hoang T, Hu Y.
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Surface protein glycosylation conserved in the human pathogen Mycoplasma genitalium and retained in the synthetic organism JCVI-Syn3A. [PDF]

PLoS One
Sanford JW, Mobley J, Dybvig K, Atkinson TP, Daubenspeck JM.   +4 more
europepmc   +1 more source