Results 81 to 90 of about 10,675,471 (331)

The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency

Nature Communications
Mitophagy is crucial for maintaining mitochondrial health, but how its levels adjust to different stress conditions remains unclear. In this study, we investigated the role of the DELE1-HRI axis of the integrated stress response (ISR) in regulating ...
Mingchong Yang, Zengshuo Mo, Kelly Walsh, Wen Liu, Imane Nait Irahal, Damien Arnoult, Xiaoyan Guo   +6 more
doaj   +1 more source

Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways

International Journal of Molecular Sciences, 2020
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which—given their dual-genetic control—requires tight co-regulation of two evolutionarily distinct gene expression machineries.
Jia Tang, K. Thompson, R. Taylor, M. Oláhová   +3 more
semanticscholar   +1 more source

Protein import into the nucleus [PDF]

FEBS Letters, 1996
The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS‐receptor which binds to a subset of proteins of the nuclear pore complex (NPC).
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Toc75‐V/OEP80 is processed during translocation into chloroplasts, and the membrane‐embedded form exposes its POTRA domain to the intermembrane space

FEBS Open Bio, 2020
The insertion of membrane proteins requires proteinaceous complexes in the cytoplasm, the membrane, and the lumen of organelles. Most of the required complexes have been described, while the components for insertion of β‐barrel‐type proteins into the ...
Lucia E. Gross, Nicole Spies, Stefan Simm, Enrico Schleiff   +3 more
doaj   +1 more source

The Arabidopsis ppi1 mutant is specifically defective in the expression, chloroplast import, and accumulation of photosynthetic proteins [PDF]

, 2003
The import of nucleus-encoded proteins into chloroplasts is mediated by translocon complexes in the envelope membranes. A component of the translocon in the outer envelope membrane, Toc34, is encoded in Arabidopsis by two homologous genes, atTOC33 and ...
Baldwin, Amy, Lilley, Kathryn, Leister, D., Kubis, Sybille, Kurth, Joachim, Kurth, J., Paul Dupree, Baldwin, Amy Joy, Razzaq, A., Dupree, Paul, Baldwin, A., Paul Jarvis, Sybille Kubis, Patel, R., Lilley, K., Azam Razzaq, Kubis, S., Leister, Dario, Amy Baldwin, Jarvis, Paul, Razzaq, Azam, Dario Leister, Kathryn Lilley, Jarvis, P., Dupree, P., Ramesh Patel, Joachim Kurth, Patel, Ramesh   +27 more
core   +1 more source

The motors of protein import into chloroplasts [PDF]

Plant Signaling & Behavior, 2011
Chloroplast function is largely dependent on its resident proteins, most of which are encoded by the nuclear genome and are synthesized in cytosol. Almost all of these are imported through the translocons located in the outer and inner chloroplast envelope membranes. The motor protein that provides the driving force for protein import has been proposed
Shi, Lan-Xin, Theg, Steven M
openaire   +4 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Isolation and characterisation of the intermembrane space components of the mitochondrial TIM22 protein import machinery of Neurospora crassa [PDF]

, 2004
Mitochondria are essential cellular organelles of eukaryotic organisms, which import most of their proteinaceous constituents from the cytoplasm. Two mitochondrial membranes contain different translocation machineries which are involved in the import and
Vasiljev, Andreja
core   +1 more source